Organizing Committee
Abstract

Mathematical models have been giving remarkable contributions in advancing knowledge and supporting decisions in several branches of medicine.

Some progress in applying predictive mathematical tools has been made, for example: surgical planning of the Total Cavopulmonary Connection in cardiac pediatrics is, in some hospitals, based on extensive numerical simulation. However, despite the significance, the impact of predictive modeling in the routine medical treatment falls behind.

The ultimate goal of this workshop is to foster collaboration between mathematicians and medical doctors on modeling cardiovascular system. The workshop is organized into two lines that reflect the special format of the workshop: (a) "Core topics" are up-to-date research areas in mathematics and scientific computing that still present several open exciting challenges, which can require developing new numerical models, computational approaches and validation techniques; (b) "New challenges" are a set of cardiovascular (in broad sense) problems and diseases that have not been attacked extensively with numerical tools.

The "core topics" will include fluid-structure interaction, multi-scale dynamics, data assimilation, while the "new challenges" will focus on the liver circulation, cardiac re-synchronization therapy, chronic venous insufficiency and coiling of intracranial aneurysms. The workshop will be based on round-table discussions in smaller groups and lectures.

Workshop Highlights

Confirmed Speakers & Participants

Workshop Schedule

Monday, January 20, 2014
TimeEventLocationMaterials
8:15 - 8:30Registration - Registration11th Floor Collaborative Space 
8:30 - 9:00Welcome & Opening - ICERM Director and Leopold Grinberg, IBM11th Floor Lecture Hall 
9:00 - 9:35A Constrained Mixture Theory for Arterial Adaptation and Disease Presentation - J. D. Humphrey, Yale University11th Floor Lecture Hall
9:45 - 10:20Hemodynamics_and_Structural Analysis of Aneurysms with Known Rupture Sites - Juan R. Cebral, George Mason University11th Floor Lecture Hall
10:30 - 10:45Coffee/Tea Break11th Floor Collaborative Space 
10:45 - 11:20The mechanobiology of the cerebral aneurysm wall: our current understanding and future research directions - Anne Robertson, University of Pittsburgh 11th Floor Lecture Hall 
11:30 - 12:05Modelling the Mechanobiology of Aneurysm Evolution - Paul Watton, University of Oxford11th Floor Lecture Hall
12:15 - 1:45Break for Lunch/Free Time  
1:45 - 2:20Model order reduction for cardiovascular modeling - Alfio Quarteroni, Ecole Polytechnique Federale de Lausanne11th Floor Lecture Hall
2:30 - 3:05Integrative analysis of coronary anatomy and physiology using computed tomography imaging - James Min and Guanglei Xiong, Cornell University11th Floor Lecture Hall
3:15 - 3:50A geometrical optimization of a by-pass graft - Torbjorn Lundh, Chalmers University of Technology and University of Gothenburg11th Floor Lecture Hall
4:00 - 4:35Discussion11th Floor Lecture Hall 
4:35 - 5:20Tutorial: Tutorial on Modeling Vascular Adaptation and Disease Progression - Jay Humphrey, Yale University 11th Floor Lecture Hall 
Tuesday, January 21, 2014
TimeEventLocationMaterials
8:30 - 9:05An anatomically detailed arterial network (ADAN) model for computational hemodynamics - Pablo Javier Blanco, National Laboratory for Scientific Computing11th Floor Lecture Hall
9:15 - 9:50Mathematical Transcatheter Aortic Valve Replacement - Suncica Canic, University of Houston11th Floor Lecture Hall
10:00 - 10:15Coffee/Tea Break11th Floor Collaborative Space 
10:15 - 10:50Multiscale modeling and optimal treatment planning in pediatric cardiology - Alison Marsden, University of California, San Diego11th Floor Lecture Hall
11:00 - 11:35Multiscale Modeling of Hematologic Disorders - George Karniadakis, Brown University11th Floor Lecture Hall
11:45 - 12:15Speed Networking Session 11th Floor Lecture Hall 
12:15 - 1:45Break for Lunch/Free Time  
1:45 - 2:20Simulation of 3-D Blood Flow in the Full Systemic Arterial Tree and Computational Frameworks for Efficient Parameter Estimation - C. Alberto Figueroa, King’s College London11th Floor Lecture Hall
2:30 - 3:05Parameter Estimation in Cardiovascular Modeling - Mette Olufsen, North Carolina State University11th Floor Lecture Hall
3:15 - 3:25Break11th Floor Collaborative Space 
3:25 - 3:45Stabilized methods for fluid-structure interaction - Yue Yu, Brown University11th Floor Lecture Hall
3:45 - 4:05An effective closure model for computational hemodynamics - Paris Perdikaris, Brown University11th Floor Lecture Hall
4:05 - 4:35Discussion11th Floor Lecture Hall 
4:35 - 5:05Tutorial: multiscale systemic modeling - Pablo Javier Blanco, National Laboratory for Scientific Computing11th Floor Lecture Hall 
5:30 - 7:00Poster Session and Networking Reception10th Floor  
Wednesday, January 22, 2014
TimeEventLocationMaterials
8:30 - 9:05Mathematical and Informatics Challenges to Translating Cardiovascular Models to Clinical Care - Raimond Winslow, Johns Hopkins University11th Floor Lecture Hall
9:15 - 9:50c-Src Inhibition Restores Conduction Velocity in Ischemic Heart Disease - Cody Rutledge, Brown University11th Floor Lecture Hall 
10:00 - 10:15Coffee/Tea Break11th Floor Collaborative Space 
10:15 - 10:50Computational analysis of energy metabolism at different scales - Daniela Calvetti, Case Western Reserve University11th Floor Lecture Hall
11:00 - 11:35Cardiomagnetism- Modeling the nonlinear magneto-elastic interactions - Luis Dorfmann, Tufts University11th Floor Lecture Hall
11:45 - 12:20MRI for Patient Selection and Lead Planning in Cardiac Resynchronization Therapy - John N. Oshinski, Emory University11th Floor Lecture Hall
12:30 - 1:45Break for Lunch/Free Time  
1:45 - 2:20From Chaos to Cures; controlling the complex spatiotemporal dynamics of cardiac arrhythmias using a computational and experimental integrative approach - Flavio Fenton, Georgia Institute of Technology11th Floor Lecture Hall 
2:30 - 3:05Novel high-resolution model of cardiac mechanics - Viatcheslav Gurev, IBM Thomas J. Watson Research Center11th Floor Lecture Hall
3:15 - 3:50Simulation with 1.5M cores enable near real-time electrophysiological heart models - J. Jeremy Rice, IBM Thomas J. Watson Research Center11th Floor Lecture Hall
4:00 - 4:45Discussion11th Floor Lecture Hall 
4:45 - 5:20Tutorial on Electrophysiology of the Heart - Sam Dudley, Brown University11th Floor Lecture Hall
Thursday, January 23, 2014
TimeEventLocationMaterials
8:15 - 9:05Tutorial on Vascular Inflamation - W. Robert Taylor, Emory University11th Floor Lecture Hall 
9:15 - 9:50What do we know about coronary plaque progression in 2014? - Habib Samady, Emory University11th Floor Lecture Hall 
10:00 - 10:15Coffee/Tea Break11th Floor Collaborative Space 
10:15 - 10:45Part 1- Transgenic Rabbits with Long QT Syndrome- A Multi-Scale Approach to Sudden Cardiac Death - Gideon Koren, Brown University11th Floor Lecture Hall
10:45 - 11:20Part 2- Cellular Mechanisms of Triggered Arrhythmias Insights from Multiscale Insilico Modeling - Alain Karma, Northeastern University11th Floor Lecture Hall
11:30 - 12:05Endothelial Cell Heterogeneity - Nature, Nurture or Neither? - Erzsebet Regan, Harvard University11th Floor Lecture Hall 
12:15 - 12:20Group Photo in Lecture Hall11th Floor Lecture Hall 
12:20 - 1:45Break for Lunch/Free Time  
1:45 - 2:20Thoracic Aortic Disease- A Multi-layered Problem and Solution in Perivascular Oversight of Vessel Homeostasis - Julie Phillippi, University of Pittsburgh11th Floor Lecture Hall
2:30 - 3:05A theoretical study of the CCSVI condition - Lucas Muller, Universita di Trento11th Floor Lecture Hall
3:15 - 3:50Hemodynamic Impact of Hydrodynamic Gene Delivery on Liver - Dexi Liu, University of Georgia11th Floor Lecture Hall
4:00 - 4:35Computational models for fluid exchange and bio-chemical transport between microcirculation and tissue interstitium. A study of drug delivery strategies to target tumors - Paolo Zunino, University of Pittsburgh11th Floor Lecture Hall
4:45 - 5:20Flow Patterns in the Abdominal Aorta- Relationships between Atherosclerosis and Aneurysm Formation - W. Robert Taylor, Emory University11th Floor Lecture Hall
5:20 - 5:50Discussion11th Floor Lecture Hall 
Friday, January 24, 2014
TimeEventLocationMaterials
8:30 - 9:05From simulations to assimilations- challenges and perspectives of bringing cardiovascular mathematics to the bedside - Alessandro Veneziani, Emory University11th Floor Lecture Hall
9:15 - 9:50Numbers and Neurons - The Expanding Role of Mathematical Analysis in Clinical Interventional Neuroradiology. - Frank Tong, Emory University11th Floor Lecture Hall 
10:00 - 10:15Coffee/Tea Break11th Floor Collaborative Space 
10:15 - 10:50A Theoretical Framework for Modeling Arterial Tissue Equivalent Evolution - Arturo Valentin, University of Pittsburgh11th Floor Lecture Hall
11:00 - 11:50Tutorial on Inverse Methods - Alessandro Veneziani, Emory University11th Floor Lecture Hall 
12:00 - 12:45Summary & Closing11th Floor Lecture Hall 

Lecture Videos

A geometrical optimization of a by-pass graft

Torbjorn Lundh
Chalmers University of Technology and University of Gothenburg
January 20, 2014