From the Clinic to Partial Differential Equations and Back: Emerging challenges for Cardiovascular Mathematics (January 20 - 24, 2014)

Organizing Committee
  • Leopold Grinberg
    (Brown University and IBM T. J. Watson Research Center)
  • Anne Marie Robertson
    (University of Pittsburgh)
  • Pablo Javier Blanco
    (National Laboratory for Scientific Computing and INCT in Medicine Assisted by Scientific Computing, Brazil)
  • Alessandro Veneziani
    (Emory University)
  • John N Oshinski
    (Emory University, School of Medicine)
  • W. Robert Taylor
    (Emory University, School of Medicine)

Mathematical models have been giving remarkable contributions in advancing knowledge and supporting decisions in several branches of medicine.

Some progress in applying predictive mathematical tools has been made, for example: surgical planning of the Total Cavopulmonary Connection in cardiac pediatrics is, in some hospitals, based on extensive numerical simulation. However, despite the significance, the impact of predictive modeling in the routine medical treatment falls behind.

The ultimate goal of this workshop is to foster collaboration between mathematicians and medical doctors on modeling cardiovascular system. The workshop is organized into two lines that reflect the special format of the workshop: (a) "Core topics" are up-to-date research areas in mathematics and scientific computing that still present several open exciting challenges, which can require developing new numerical models, computational approaches and validation techniques; (b) "New challenges" are a set of cardiovascular (in broad sense) problems and diseases that have not been attacked extensively with numerical tools.

The "core topics" will include fluid-structure interaction, multi-scale dynamics, data assimilation, while the "new challenges" will focus on the liver circulation, cardiac re-synchronization therapy, chronic venous insufficiency and coiling of intracranial aneurysms. The workshop will be based on round-table discussions in smaller groups and lectures.

  • Ian Alevy
    (Brown University)
  • Pablo Blanco*
    (National Laboratory for Scientific Computing)
  • Martina Bukac
    (University of Pittsburgh)
  • Daniela Calvetti *
    (Case Western Reserve University)
  • Suncica Canic *
    (University of Houston)
  • Juan Cebral *
    (George Mason University)
  • Bong Jae Chung
    (George Mason University)
  • Andjela Davidovic
  • Paolo Di Achille
    (Yale University)
  • Luis Dorfmann *
    (Tufts University)
  • Xinjie Duan
    (University of Pittsburgh)
  • Sam Dudley *
    (Brown University)
  • Andrea Dzinbek
  • Laura Ellwein
    (Virginia Commonwealth University)
  • Carrie Falke
    (Louisiana Tech University)
  • Angiolo Farina
    (University of Florence)
  • Flavio Fenton *
    (Georgia Institute of Technology)
  • Carlos Figueroa *
    (Kings College London)
  • Davide Forti
    (EPFL - École Polytechnique Fédérale de Lausanne)
  • Lorenzo Fusi
    (University of Florence)
  • Paolo Gatto
    (Brown University)
  • Luca Gerardo Giorda
    (BCAM - Basque Center for Applied Mathematics)
  • Daniel Golbert
    (Brown University)
  • Venu Gopal
    (University of Delhi)
  • Stephen Greenwald
    (Queen Mary University of London)
  • Pierre Gremaud
    (North Carolina State Univ.)
  • Leopold Grinberg *
  • Viatcheslav Gurev*
  • Jay Humphrey *
    (Yale University)
  • Elizabeth Iffrig
    (Emory University & Georgia Institute of Technology)
  • Sunil Kandel
    (Oakland University)
  • Alain Karma*
    (Northeastern University)
  • George Karniadakis *
    (Brown University)
  • Tae Kim
    (Brown University)
  • Gideon Koren*
    (Brown University)
  • Kevin Lau
    (Kings College London)
  • Xuejin Li
    (Brown University)
  • Zhen Li
    (Brown University)
  • Dexter Liu *
    (University of Georgia)
  • Torbjörn Lundh *
  • Alison Marsden *
    (University of California, San Diego)
  • Lucas Muller*
    (Università di Trento)
  • Mette Olufsen *
    (North Carolina State University)
  • Saulo Orizaga
    (Iowa State University)
  • John Oshinski*
    (Emory University)
  • Zhangli Peng
    (Massachusetts Institute of Technology)
  • Paris Perdikaris*
    (Brown University)
  • Gustavo Perla Menzala
    (Laboratorio Nacional de Computacao Cientifica)
  • Julie Phillippi*
    (University of Pittsburgh)
  • Alfio Quarteroni *
    (École Polytechnique Fédérale de Lausanne (EPFL))
  • Ramsharan Rangarajan
    (Brown University)
  • Erzsebet Regan *
    (Harvard University)
  • John Rice*
  • Anne Robertson *
    (University of Pittsburgh)
  • Jenn Rossmann
    (Lafayette College)
  • Cody Rutledge*
    (Brown University)
  • Habib Samady*
    (Emory University)
  • Simon Shaw
    (Brunel University)
  • Erkki Somersalo
    (Case Western Reserve University)
  • Raymond Spiteri
    (University of Saskatchewan)
  • Yi Sun
    (University of South Carolina)
  • Marcela Szopos
    (University of Strasbourg)
  • W. Robert Taylor *
    (Emory University)
  • Frank Tong*
    (Emory University)
  • Arturo Valentin*
    (University of Pittsburgh)
  • Alessandro Veneziani *
    (Emory University)
  • Daniele Venturi
    (Brown University)
  • Mario Sansuke Watanabe
    (Laboratorio Nacional de Computacao Cientifica-LNCC)
  • Paul Watton*
    (University of Oxford)
  • Raimond Winslow*
    (Johns Hopkins University)
  • Alexandra Witthoft
    (Brown University)
  • Ghomglei Xiong*
    (Cornell University)
  • Alireza Yazdani
    (Brown University)
  • Yue Yu*
    (Brown University)
  • Paolo Zunino *
    (University of Pittsburgh)
MondayJanuary 20, 2014
8:15 - 8:30RegistrationRegistration11th Floor Collaborative Space
8:30 - 9:00Welcome & OpeningICERM Director and Leopold Grinberg, IBM11th Floor Lecture Hall
9:00 - 9:35A Constrained Mixture Theory for Arterial Adaptation and Disease PresentationJ. D. Humphrey, Yale University11th Floor Lecture Hall
9:45 - 10:20Hemodynamics_and_Structural Analysis of Aneurysms with Known Rupture SitesJuan R. Cebral, George Mason University11th Floor Lecture Hall
10:30 - 10:45Coffee/Tea Break11th Floor Collaborative Space
10:45 - 11:20The mechanobiology of the cerebral aneurysm wall: our current understanding and future research directionsAnne Robertson, University of Pittsburgh 11th Floor Lecture Hall
11:30 - 12:05Modelling the Mechanobiology of Aneurysm EvolutionPaul Watton, University of Oxford11th Floor Lecture Hall
12:15 - 1:45Break for Lunch/Free Time
1:45 - 2:20Model order reduction for cardiovascular modelingAlfio Quarteroni, Ecole Polytechnique Federale de Lausanne11th Floor Lecture Hall
2:30 - 3:05Integrative analysis of coronary anatomy and physiology using computed tomography imagingJames Min and Guanglei Xiong, Cornell University11th Floor Lecture Hall
3:15 - 3:50A geometrical optimization of a by-pass graftTorbjorn Lundh, Chalmers University of Technology and University of Gothenburg11th Floor Lecture Hall
4:00 - 4:35Discussion11th Floor Lecture Hall
4:35 - 5:20Tutorial: Tutorial on Modeling Vascular Adaptation and Disease ProgressionJay Humphrey, Yale University 11th Floor Lecture Hall

TuesdayJanuary 21, 2014
8:30 - 9:05An anatomically detailed arterial network (ADAN) model for computational hemodynamicsPablo Javier Blanco, National Laboratory for Scientific Computing11th Floor Lecture Hall
9:15 - 9:50Mathematical Transcatheter Aortic Valve ReplacementSuncica Canic, University of Houston11th Floor Lecture Hall
10:00 - 10:15Coffee/Tea Break11th Floor Collaborative Space
10:15 - 10:50Multiscale modeling and optimal treatment planning in pediatric cardiologyAlison Marsden, University of California, San Diego11th Floor Lecture Hall
11:00 - 11:35Multiscale Modeling of Hematologic DisordersGeorge Karniadakis, Brown University11th Floor Lecture Hall
11:45 - 12:15Speed Networking Session 11th Floor Lecture Hall
12:15 - 1:45Break for Lunch/Free Time
1:45 - 2:20Simulation of 3-D Blood Flow in the Full Systemic Arterial Tree and Computational Frameworks for Efficient Parameter EstimationC. Alberto Figueroa, King’s College London11th Floor Lecture Hall
2:30 - 3:05Parameter Estimation in Cardiovascular ModelingMette Olufsen, North Carolina State University11th Floor Lecture Hall
3:15 - 3:25Break11th Floor Collaborative Space
3:25 - 3:45Stabilized methods for fluid-structure interactionYue Yu, Brown University11th Floor Lecture Hall
3:45 - 4:05An effective closure model for computational hemodynamicsParis Perdikaris, Brown University11th Floor Lecture Hall
4:05 - 4:35Discussion11th Floor Lecture Hall
4:35 - 5:05Tutorial: multiscale systemic modelingPablo Javier Blanco, National Laboratory for Scientific Computing11th Floor Lecture Hall
5:30 - 7:00Poster Session and Networking Reception10th Floor

WednesdayJanuary 22, 2014
8:30 - 9:05Mathematical and Informatics Challenges to Translating Cardiovascular Models to Clinical CareRaimond Winslow, Johns Hopkins University11th Floor Lecture Hall
9:15 - 9:50c-Src Inhibition Restores Conduction Velocity in Ischemic Heart DiseaseCody Rutledge, Brown University11th Floor Lecture Hall
10:00 - 10:15Coffee/Tea Break11th Floor Collaborative Space
10:15 - 10:50Computational analysis of energy metabolism at different scalesDaniela Calvetti, Case Western Reserve University11th Floor Lecture Hall
11:00 - 11:35Cardiomagnetism- Modeling the nonlinear magneto-elastic interactionsLuis Dorfmann, Tufts University11th Floor Lecture Hall
11:45 - 12:20MRI for Patient Selection and Lead Planning in Cardiac Resynchronization TherapyJohn N. Oshinski, Emory University11th Floor Lecture Hall
12:30 - 1:45Break for Lunch/Free Time
1:45 - 2:20From Chaos to Cures; controlling the complex spatiotemporal dynamics of cardiac arrhythmias using a computational and experimental integrative approachFlavio Fenton, Georgia Institute of Technology11th Floor Lecture Hall
2:30 - 3:05Novel high-resolution model of cardiac mechanicsViatcheslav Gurev, IBM Thomas J. Watson Research Center11th Floor Lecture Hall
3:15 - 3:50Simulation with 1.5M cores enable near real-time electrophysiological heart modelsJ. Jeremy Rice, IBM Thomas J. Watson Research Center11th Floor Lecture Hall
4:00 - 4:45Discussion11th Floor Lecture Hall
4:45 - 5:20Tutorial on Electrophysiology of the HeartSam Dudley, Brown University11th Floor Lecture Hall

ThursdayJanuary 23, 2014
8:15 - 9:05Tutorial on Vascular Inflamation W. Robert Taylor, Emory University11th Floor Lecture Hall
9:15 - 9:50What do we know about coronary plaque progression in 2014?Habib Samady, Emory University11th Floor Lecture Hall
10:00 - 10:15Coffee/Tea Break11th Floor Collaborative Space
10:15 - 10:45Part 1- Transgenic Rabbits with Long QT Syndrome- A Multi-Scale Approach to Sudden Cardiac DeathGideon Koren, Brown University11th Floor Lecture Hall
10:45 - 11:20Part 2- Cellular Mechanisms of Triggered Arrhythmias Insights from Multiscale Insilico ModelingAlain Karma, Northeastern University11th Floor Lecture Hall
11:30 - 12:05Endothelial Cell Heterogeneity - Nature, Nurture or Neither?Erzsebet Regan, Harvard University11th Floor Lecture Hall
12:15 - 12:20Group Photo in Lecture Hall11th Floor Lecture Hall
12:20 - 1:45Break for Lunch/Free Time
1:45 - 2:20Thoracic Aortic Disease- A Multi-layered Problem and Solution in Perivascular Oversight of Vessel HomeostasisJulie Phillippi, University of Pittsburgh11th Floor Lecture Hall
2:30 - 3:05A theoretical study of the CCSVI conditionLucas Muller, Universita di Trento11th Floor Lecture Hall
3:15 - 3:50Hemodynamic Impact of Hydrodynamic Gene Delivery on LiverDexi Liu, University of Georgia11th Floor Lecture Hall
4:00 - 4:35Computational models for fluid exchange and bio-chemical transport between microcirculation and tissue interstitium. A study of drug delivery strategies to target tumorsPaolo Zunino, University of Pittsburgh11th Floor Lecture Hall
4:45 - 5:20Flow Patterns in the Abdominal Aorta- Relationships between Atherosclerosis and Aneurysm FormationW. Robert Taylor, Emory University11th Floor Lecture Hall
5:20 - 5:50Discussion11th Floor Lecture Hall

FridayJanuary 24, 2014
8:30 - 9:05From simulations to assimilations- challenges and perspectives of bringing cardiovascular mathematics to the bedsideAlessandro Veneziani, Emory University11th Floor Lecture Hall
9:15 - 9:50Numbers and Neurons - The Expanding Role of Mathematical Analysis in Clinical Interventional Neuroradiology.Frank Tong, Emory University11th Floor Lecture Hall
10:00 - 10:15Coffee/Tea Break11th Floor Collaborative Space
10:15 - 10:50A Theoretical Framework for Modeling Arterial Tissue Equivalent EvolutionArturo Valentin, University of Pittsburgh11th Floor Lecture Hall
11:00 - 11:50Tutorial on Inverse MethodsAlessandro Veneziani, Emory University11th Floor Lecture Hall
12:00 - 12:45Summary & Closing11th Floor Lecture Hall

      Workshop Highlights