Organizing Committee
 Carina Curto
The Pennsylvania State University  Brent Doiron
University of Chicago  Robert Ghrist
University of Pennsylvania  Kathryn Hess
EPFL  Zachary Kilpatrick
University of Colorado Boulder  Matilde Marcolli
California Institute of Technology  Konstantin Mischaikow
Rutgers University  Katie Morrison
University of Northern Colorado  Elad Schneidman
Weizmann Institute of Science  Tatyana Sharpee
Salk Institute
Abstract
The goal of this Semester Program is to bring together a variety of mathematicians with researchers working in theoretical and computational neuroscience as well as some theoryfriendly experimentalists. However, unlike programs in neuroscience that emphasize connections between theory and experiment, this program will focus on building bridges between theory and mathematics. This is motivated in part by the observation that theoretical developments in neuroscience are often limited not only by lack of data but also by the need to better develop the relevant mathematics. For example, theorists often rely on linear or nearlinear modeling frameworks for neural networks simply because the mathematics of nonlinear network dynamics is still poorly understood. Conversely, just as in the history of physics, neuroscience problems give rise to new questions in mathematics. In recent years, these questions have touched on a rich variety of fields including geometry, topology, combinatorics, dynamical systems, and algebra. We believe the time has come to deepen these connections and foster new interactions and collaborations between neuroscientists who think deeply about theory and mathematicians who are looking for new problems inspired by science. In addition to collaborative research between theorists and mathematicians, an explicit goal of the program will be to produce an “open problems” document. This document will present a series of wellformulated open math problems together with explanations of their neuroscience motivation, partial progress, and the potential significance of their solutions.
Confirmed Speakers & Participants
Talks will be presented virtually or inperson as indicated in the schedule below.
 Speaker
 Poster Presenter
 Attendee
 Virtual Attendee

Arman Afrasiyabi
Yale UniversityOct 30Nov 3, 2023

Yashar Ahmadian
Cambridge UniversitySep 1822, 2023

Asohan Amarasingham
City College, CUNYOct 30Nov 3, 2023

Daniele Avitabile
Vrije Universiteit AmsterdamSep 20Dec 15, 2023

Huseyin Ayhan
Florida State UniversityOct 1620, 2023

Demba Ba
Harvard UniversitySep 1822, 2023

Aishwarya Balwani
Georgia Institute of TechnologyOct 1620, 2023

Andrea Barreiro
Southern Methodist UniversitySep 1Dec 22, 2023

Robin Belton
Smith CollegeSep 1822, 2023

Marcus Benna
UC San DiegoSep 1822, 2023

Leonid Berlyand
Penn StateOct 56, 2023

Dhananjay Bhaskar
Yale UniversityOct 1620, 2023

Ginestra Bianconi
Queen Mary University of LondonOct 1620, 2023

Prianka Bose
New Jersey Institute of TechnologySep 1822, 2023

Amitabha Bose
New Jersey Institute of TechnologySep 15Nov 17, 2023

Felipe Branco de Paiva
University of WisconsinMadisonOct 1620, 2023

Robyn Brooks
University of UtahSep 1Dec 31, 2023

Peter Bubenik
University of FloridaSep 1822, 2023; Oct 1620, 2023

Michael Buice
Allen InstituteSep 1822, 2023

Thomas Burns
ICERMAug 31Dec 31, 2023

Johnathan Bush
University of FloridaOct 1620, 2023

Carlos Castañeda Castro
Brown UniversitySep 6Dec 8, 2023

Francesca Cavallini
Vrije Universiteit AmsterdamOct 1620, 2023

Teressa Chambers
Brown UniversityOct 30Nov 3, 2023

Rishidev Chaudhuri
University of California, DavisSep 1822, 2023

Dmitri Chklovskii
Flatiron Institute & NYU Neuroscience InstituteOct 1620, 2023

Hannah Choi
Georgia Institute of TechnologyOct 30Nov 3, 2023

Sehun Chun
Yonsei UniversitySep 1822, 2023

Heather Cihak
University of Colorado BoulderSep 1822, 2023

Giovanna Citti
university of BolognaSep 17Nov 3, 2023

Natasha Crepeau
University of WashingtonOct 30Nov 3, 2023

Justin Curry
University at Albany SUNYOct 1620, 2023

Julie Curtis
University of WashingtonOct 30Nov 3, 2023

Carina Curto
The Pennsylvania State UniversitySep 1Dec 9, 2023

Rodica Curtu
The University of IowaSep 1822, 2023; Oct 29Nov 3, 2023

Steve Damelin
Mathematical Scientist, Ann Arbor MISep 1722, 2023; Oct 30Nov 3, 2023

Maria Dascalu
University of Massachusetts AmherstOct 29Nov 4, 2023

Anda Degeratu
University of StuttgartSep 17Oct 7, 2023

Juan Carlos DíazPatiño
Universidad Nacional Autónoma de MéxicoOct 1620, 2023

Darcy Diesburg
Brown UniversitySep 1822, 2023

Fatih Dinc
Stanford UniversitySep 1822, 2023

Brent Doiron
University of ChicagoSep 1723, 2023

Benjamin Dunn
Norwegian University of Science and TechnologyOct 1620, 2023

Julia E Grigsby
Boston CollegeOct 30Nov 3, 2023

Ahmed elhady
Konstanz Center for Advanced Study of Collective BehaviorNov 130, 2023

Sophia Epstein
University of Texas at AustinOct 1620, 2023

Aysel Erey
Utah State UniversityOct 30Nov 3, 2023

Sean Escola
Columbia UniversitySep 1822, 2023

Julio Esparza Ibanez
Instituto Cajal  CSIC (Spanish National Research Council)Oct 1626, 2023

Ashkan Faghiri
Georgia state universityOct 1620, 2023

Matthew Farrell
Harvard UniversitySep 1822, 2023

Richard Foster
Virginia Commonwealth UniversitySep 1822, 2023

Michael Frank
Brown UniversitySep 6Dec 8, 2023

Halley Fritze
University of OregonOct 1620, 2023

Marcio Gameiro
Rutgers UniversitySep 6Dec 8, 2023

Tomas Gedeon
Montana State UniversitySep 11Nov 1, 2023

Maria Geffen
University of PennsylvaniaNov 13, 2023

Tim Gentner
University of California, San DiegoOct 30Nov 3, 2023

Juliann Geraci
University of Nebraska LincolnOct 30Nov 10, 2023

Robert Ghrist
University of PennsylvaniaOct 1920, 2023

Chad Giusti
University of DelawareSep 1730, 2023; Oct 15Nov 6, 2023

Harold Xavier Gonzalez
Stanford UniversitySep 622, 2023

Anna Grim
Allen InstituteOct 1620, 2023

Robert Gütig
Charité Medical School BerlinOct 1620, 2023

Todd Hagen
Bernstein Center for Computational NeuroscienceOct 1620, 2023

Erik Hermansen
Norwegian University of SciencOct 1620, 2023

Abigail Hickok
Columbia UniversityOct 1520, 2023

Christian Hirsch
Aarhus UniversityOct 1620, 2023

Betty Hong
California Institute of TechnologyOct 30Nov 3, 2023

Iris Horng
University of PennsylvaniaOct 1521, 2023

Chengcheng Huang
University of PittsburghSep 1822, 2023

ChingPeng Huang
UKEOct 1620, 2023

Vladimir Itskov
The Pennsylvania State UniversitySep 5Dec 8, 2023

Jonathan Jaquette
New Jersey Institute of TechnologySep 1822, 2023

Yuchen Jiang
Australian National UniversityOct 1620, 2023

Alvin Jin
BerkeleyOct 1521, 2023

Kresimir Josic
University of HoustonSep 1822, 2023

Shabnam Kadir
University of HertfordshireOct 30Nov 3, 2023

Sameer Kailasa
University of Michigan Ann ArborSep 5Dec 9, 2023

Lida Kanari
EPFL/Blue BrainOct 1620, 2023

Gabriella Keszthelyi
Alfréd Rényi Institute of MathematicsSep 1622, 2023

Roozbeh Kiani
New York UniversityOct 30Nov 3, 2023

Zachary Kilpatrick
University of Colorado BoulderSep 1822, 2023; Oct 30Nov 3, 2023

Soon Ho Kim
Georgia Institute of TechnologySep 1822, 2023; Oct 30Nov 3, 2023

Hyunjoong Kim
University of HoustonSep 1723, 2023

Christopher Kim
National Institutes of HealthSep 1822, 2023

Kevin Knudson
University of FloridaOct 1620, 2023

Leo Kozachkov
Massachusetts Institute of TechnologySep 1822, 2023

Maxwell Kreider
Case Western Reserve UniversitySep 6Dec 8, 2023

Kishore Kuchibhotla
Johns Hopkins UniversityOct 1620, 2023

Ankit Kumar
UC BerkeleySep 1822, 2023

Alexander Kunin
Creighton UniversityOct 813, 2023

Giancarlo La Camera
Stony Brook UniversityOct 1620, 2023

KangJu Lee
Seoul National UniversityOct 1521, 2023

Ran Levi
University of AberdeenOct 1620, 2023

Noah Lewis
Georgia Institute of TechnologyOct 1620, 2023

Zelong Li
Penn State UniversitySep 5Dec 9, 2023

Yao Li
University of Massachusetts AmherstSep 6Dec 8, 2023

Johnny Li
UCSDOct 1620, 2023

Caitlin Lienkaemper
Boston UniversitySep 15Nov 4, 2023

Kathryn Lindsey
Boston CollegeSep 6Dec 8, 2023

Justin Lines
Columbia UniversityOct 30Nov 3, 2023

Vasiliki Liontou
ICERMSep 6Dec 8, 2023

David Lipshutz
Flatiron InstituteSep 1822, 2023

Sijing Liu
Brown UniversitySep 1, 2023May 31, 2024

Jessica Liu
CUNY Graduate CenterSep 1822, 2023

Simon Locke
Johns Hopkins UniversitySep 1822, 2023

Laureline Logiaco
Massachusetts Institute of TechnologySep 1822, 2023

Juliana Londono Alvarez
Penn StateSep 6Dec 8, 2023

Caio Lopes
École Polytechnique Fédérale de LausanneOct 1620, 2023

Christian Machens
Champalimaud FoundationOct 30Nov 3, 2023

James MACLAURIN
New Jersey Institute of TechnologySep 1822, 2023

Matilde Marcolli
California Institute of TechnologySep 6Dec 8, 2023; Sep 1822, 2023; Oct 1620, 2023

Marissa Masden
ICERMSep 6, 2023May 31, 2024

Sarah Mason
Wake Forest UniversityOct 30Nov 3, 2023

Leenoy Meshulam
University of WashingtonOct 30Nov 3, 2023

Nikola Milicevic
Pennsylvania State UniversitySep 1Dec 10, 2023

Federica Milinanni
KTH  Royal Institute of TechnologySep 17Nov 5, 2023

Konstantin Mischaikow
Rutgers UniversitySep 1723, 2023; Sep 1822, 2023; Oct 56, 2023

Katie Morrison
University of Northern ColoradoSep 1Dec 10, 2023

Noga Mudrik
The Johns Hopkins UniversitySep 1822, 2023

Audrey Nash
Florida State UniversitySep 1822, 2023

matt nassar
Brown UniversitySep 6Dec 8, 2023

Junalyn NavarraMadsen
TEXAS WOMAN'S UNIVERSITYOct 30Nov 3, 2023

Ilya Nemenman
Emory UniversityOct 30Nov 3, 2023

Fernando Nobrega Santos
University of AmsterdamOct 1521, 2023

Gabe Ocker
Boston UniversitySep 6Dec 8, 2023

Choongseok Park
NC A&T State UniversitySep 1822, 2023

Ross Parker
Center for Communications Research – PrincetonSep 1822, 2023; Oct 1620, 2023

Caitlyn Parmelee
Keene State CollegeSep 5Dec 9, 2023

alice patania
University of VermontOct 1620, 2023

Cengiz Pehlevan
Harvard UniversitySep 6Dec 8, 2023

Isabella Penido
Brown UniversitySep 6Dec 8, 2023

Jose Perea
Northeastern UniversitySep 6Dec 8, 2023

Giovanni Petri
CENTAI InstituteOct 1620, 2023

Mason Porter
UCLASep 1822, 2023

Rebecca R.G.
George Mason UniversityOct 29Nov 3, 2023

Allan Raventos
Stanford UniversitySep 1822, 2023

Niloufar Razmi
Brown UniversitySep 6Dec 8, 2023

Alex Reyes
New York UniversityOct 1620, 2023

Antonio Rieser
Centro de Investigación en MatemáticasSep 5Dec 9, 2023

Dmitry Rinberg
New York UniversityOct 1620, 2023

Dario Ringach
University of California, Los AngelesOct 1620, 2023

Jason Ritt
Brown UniversitySep 6Dec 8, 2023

Robert Rosenbaum
University of Notre DameSep 1822, 2023

Horacio Rotstein
New Jersey Institute of TechnologySep 5Nov 3, 2023

Jennifer Rozenblit
University of Texas, AustinOct 1620, 2023

Safaan Sadiq
Pennsylvania State UniversitySep 5Dec 9, 2023

Nicole Sanderson
Penn State UniversitySep 1Dec 31, 2023

Hannah Santa Cruz
Penn StateSep 5Dec 9, 2023

Alessandro Sarti
National Center of Scientific Research, EHESS, ParisOct 1322, 2023

Cristina Savin
NYUOct 30Nov 3, 2023

Elad Schneidman
Weizmann Institute of ScienceOct 30Nov 4, 2023

Nikolas Schonsheck
University of DelawareOct 15Nov 4, 2023

David Schwab
City University of New YorkSep 5Dec 9, 2023

Daniel Scott
Brown UniversitySep 6Dec 8, 2023

Thomas Serre
Brown UniversitySep 6Dec 8, 2023

Tatyana Sharpee
Salk InstituteOct 1620, 2023; Oct 30Nov 3, 2023

Sage Shaw
University of Colorado BoulderSep 1822, 2023

Nimrod Sherf
University of HoustonSep 1822, 2023

Patrick Shipman
Colorado State UniversityOct 1720, 2023

Farshad Shirani
Georgia Institute of TechnologySep 1822, 2023

Michael Shub
The City College of New YorkSep 1822, 2023

Paramjeet Singh
Thapar Institute of Engineering & TechnologySep 1822, 2023

Bernadette Stolz
EPFLOct 1620, 2023

Thibaud Taillefumier
UT AustinOct 30Nov 3, 2023

Evelyn Tang
Rice UniversityOct 1620, 2023

Gaia Tavoni
Washington University in St. LouisOct 30Nov 3, 2023

Dane Taylor
University of WyomingSep 1722, 2023; Oct 1520, 2023

Peter Thomas
Case Western Reserve UniversitySep 5Dec 9, 2023

Tobias Timofeyev
University of VermontSep 1822, 2023; Oct 1620, 2023

Nicholas Tolley
Brown UniversitySep 6Dec 8, 2023

Magnus Tournoy
Flatiron InstituteSep 17Oct 21, 2023

Taro Toyoizumi
Riken Center for Brain ScienceOct 30Nov 3, 2023

Wilson Truccolo
Brown UniversitySep 6Dec 8, 2023

Ka Nap Tse
University of PittsburghSep 10Dec 9, 2023

Yuki Tsukada
Keio UniversityOct 30Nov 3, 2023

Junyi Tu
Salisbury UniversityOct 1620, 2023

Srinivas Turaga
HHMI  Janelia Research CampusOct 1620, 2023

Melvin Vaupel
Norwegian Institute of Science and TechnologyOct 1620, 2023

Jonathan Victor
Weill Cornell Medical CollegeOct 1620, 2023

Elizabeth Vidaurre
Molloy UniversityOct 1620, 2023

Bradley Vigil
Texas Tech UniversityOct 1620, 2023

Juan Pablo Vigneaux
CaltechOct 30Nov 3, 2023

Zhengchao Wan
University of California San DiegoOct 1620, 2023

Xinyi Wang
Michigan State UniversitySep 10Oct 27, 2023

Bin Wang
University of California, San DiegoSep 6Dec 22, 2023

Yangyang Wang
Brandeis UniversitySep 1822, 2023

ZhuoCheng Xiao
New York UniversitySep 1822, 2023; Oct 1620, 2023

Iris Yoon
Wesleyan UniversitySep 6Dec 8, 2023

Ryeongkyung Yoon
University of HoustonSep 1822, 2023

Kei Yoshida
Brown UniversitySep 1822, 2023

Kisung You
City University of New YorkOct 1620, 2023

LaiSang Young
Courant InstituteSep 1822, 2023

Nora Youngs
Colby CollegeSep 5Dec 10, 2023

Zhuojun Yu
Case Western Reserve UniversitySep 5Dec 9, 2023

Gexin Yu
College of William and MarySep 1723, 2023

Wenhao Zhang
UT Southwestern Medical CenterSep 1822, 2023; Oct 1620, 2023

Ling Zhou
ICERMSep 6Dec 8, 2023

Robert Zielinski
Brown UniversitySep 6Dec 8, 2023
Visit dates listed on the participant list may be tentative and subject to change without notice.
Semester Schedule
Wednesday, September 6, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00 am  3:00 pm EDTCheck In11th Floor Collaborative Space

10:00  11:00 am EDTOranizer/Directorate MeetingMeeting  11th Floor Conference Room

4:00  5:00 pm EDTInformal Coffee/Tea WelcomeCoffee Break  11th Floor Collaborative Space
Thursday, September 7, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00  9:30 am EDTICERM WelcomeWelcome  11th Floor Lecture Hall

9:30  11:30 am EDTOrganizer Welcome and IntroductionsOpening Remarks  11th Floor Lecture Hall

3:00  3:30 pm EDTCoffee Break11th Floor Collaborative Space
Friday, September 8, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

10:00  11:00 am EDTGrad Student/Postdoc Meeting with ICERM DirectorateMeeting  11th Floor Lecture Hall

12:00  2:00 pm EDTPlanning LunchWorking Lunch  11th Floor Collaborative Space

3:00  3:30 pm EDTCoffee Break11th Floor Collaborative Space
Monday, September 11, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

10:00  11:30 am EDTJournal Club & Neuro 101 PlanningMeeting  11th Floor Lecture Hall

1:45  1:50 pm EDTXavier Gonzalez IntroductionLightning Talks  11th Floor Lecture Hall
 Harold Xavier Gonzalez, Stanford University

1:50  1:55 pm EDTMaxwell Kreider IntroductionLightning Talks  11th Floor Lecture Hall
 Maxwell Kreider, Case Western Reserve University

1:55  2:00 pm EDTJuliana Londono Alvarez IntroductionLightning Talks  11th Floor Lecture Hall
 Juliana Londono Alvarez, Penn State

2:00  2:05 pm EDTSafaan Sadiq IntroductionLightning Talks  11th Floor Lecture Hall
 Safaan Sadiq, Pennsylvania State University

2:05  2:10 pm EDTHannah Santa Cruz IntroductionLightning Talks  11th Floor Lecture Hall
 Hannah Santa Cruz, Penn State

2:10  2:15 pm EDTNicholas Tolley IntroductionLightning Talks  11th Floor Lecture Hall
 Nicholas Tolley, Brown University

2:15  2:20 pm EDTKa Nap Tse IntroductionLightning Talks  11th Floor Lecture Hall
 Ka Nap Tse, University of Pittsburgh

2:20  2:25 pm EDTBin Wang IntroductionLightning Talks  11th Floor Lecture Hall
 Bin Wang, University of California, San Diego

2:25  2:30 pm EDTZhuojun Yu IntroductionLightning Talks  11th Floor Lecture Hall
 Zhuojun Yu, Case Western Reserve University

2:30  2:35 pm EDTRobert Zielinkski IntroductionLightning Talks  11th Floor Lecture Hall
 Robert Zielinski, Brown University

2:35  2:40 pm EDTZelong Li IntorductionLightning Talks  11th Floor Lecture Hall
 Zelong Li, Penn State University

2:40  2:45 pm EDTSameer Kailasa IntroductionLightning Talks  11th Floor Lecture Hall
 Sameer Kailasa, University of Michigan Ann Arbor

2:45  2:50 pm EDTElena Wang IntroductionLightning Talks  11th Floor Lecture Hall
 Xinyi Wang, Michigan State University

3:00  3:30 pm EDTCoffee Break11th Floor Collaborative Space

3:30  3:40 pm EDTRobyn Brooks IntroductionLightning Talks  11th Floor Lecture Hall
 Robyn Brooks, University of Utah

3:40  3:50 pm EDTThomas Burns IntroductionLightning Talks  11th Floor Lecture Hall
 Thomas Burns, ICERM

3:50  4:00 pm EDTCaitlin Leinkaemper IntroductionLightning Talks  11th Floor Lecture Hall
 Caitlin Lienkaemper, Boston University

4:00  4:10 pm EDTVasiliki Liontou IntroductionLightning Talks  11th Floor Lecture Hall
 Vasiliki Liontou, ICERM

4:10  4:20 pm EDTSijing Liu IntroductionLightning Talks  11th Floor Lecture Hall
 Sijing Liu, Brown University

4:20  4:30 pm EDTMarissa Masden IntroductionLightning Talks  11th Floor Lecture Hall
 Marissa Masden, ICERM

4:30  4:40 pm EDTNikola Milicevic IntroductionLightning Talks  11th Floor Lecture Hall
 Nikola Milicevic, Pennsylvania State University

4:40  4:50 pm EDTNicole SandersonLightning Talks  11th Floor Lecture Hall
 Nicole Sanderson, Penn State University

4:50  5:00 pm EDTLing Zhou IntroductionLightning Talks  11th Floor Lecture Hall
 Ling Zhou, ICERM

5:00  6:30 pm EDTWelcome ReceptionReception  11th Floor Collaborative Space
Tuesday, September 12, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

10:30 am  12:00 pm EDTTDA 101Tutorial  11th Floor Lecture Hall
 Nicole Sanderson, Penn State University

3:00  3:30 pm EDTCoffee Break11th Floor Collaborative Space
Wednesday, September 13, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

10:30 am  12:00 pm EDTNetwork Dynamics & ModelingTutorial  11th Floor Lecture Hall
 Horacio Rotstein, New Jersey Institute of Technology

3:00  3:30 pm EDTCoffee Break11th Floor Collaborative Space

3:30  4:30 pm EDTClosedloop neuromechanical motor control models (or) On the importance of taking the body into account when modeling neuronal dynamics.11th Floor Lecture Hall
 Peter Thomas, Case Western Reserve University
Abstract
The central nervous system is strongly coupled to the body. Through peripheral receptors and effectors, it is also coupled to the constantly changing outside world. A chief function of the brain is to close the loop between sensory inputs and motor output. It is through the brain's effectiveness as a control mechanism for the body, embedded in the external world, that it facilitates longterm survival. Thus to understand brain circuits (one might argue) one must also understand their behavioral and ecological context. However, studying closedloop brainbody interactions is challenging experimentally, conceptually, and mathematically. In order to make progress, we focus on systems that generate rhythmic behaviors in order to accomplish a quantifiable goal, such as maintaining different forms of homeostasis. Time permitting, I'll mention two such systems, 1. control of feeding motions in the marine mollusk Aplysia californica, and 2. rhythm generation and control in the mammalian breathing system. In both of these systems, we propose that robustness in the face of variable metabolic or external demands arises from the interplay of multiple layers of control involving biomechanics, central neural dynamics, and sensory feedback.
Thursday, September 14, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00  10:30 am EDTNetwork Dynamics & Modeling (Part 2)Tutorial  11th Floor Lecture Hall
 Horacio Rotstein, New Jersey Institute of Technology

12:00  1:30 pm EDTOpen Problems fo TLNs (Bring Your Own Lunch)Problem Session  11th Floor Lecture Hall
 Session Chairs
 Carina Curto, The Pennsylvania State University
 Katie Morrison, University of Northern Colorado

2:00  2:30 pm EDTTDA softwareTutorial  11th Floor Lecture Hall
 Nicole Sanderson, Penn State University

3:00  3:30 pm EDTCoffee Break/ Neuro 101Coffee Break  11th Floor Collaborative Space
Friday, September 15, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:30  10:30 am EDTJournal Club11th Floor Lecture Hall
 Moderators
 Harold Xavier Gonzalez, Stanford University
 Sameer Kailasa, University of Michigan Ann Arbor

11:00  11:30 am EDTMathematical Challenges in Neuronal Network DynamicsPost Doc/Graduate Student Seminar  11th Floor Lecture Hall
 Marissa Masden, ICERM
Abstract
I will introduce a straightforward construction of the canonical polyhedral complex given by the activation patterns of a ReLU neural network. Then, I will describe how labeling the vertices of this polyhedral complex with sign vectors is (almost always) enough information to generate a cellular (co)chain complex labeling all of the polyhedral cells, and how this allows us to extract information about the decision boundary of the network.

11:30 am  12:00 pm EDTDetecting danger in gridworlds using Gromov's Link ConditionPost Doc/Graduate Student Seminar  11th Floor Lecture Hall
 Thomas Burns, ICERM
Abstract
Gridworlds have been longutilised in AI research, particularly in reinforcement learning, as they provide simple yet scalable models for many realworld applications such as robot navigation, emergent behaviour, and operations research. We initiate a study of gridworlds using the mathematical framework of reconfigurable systems and state complexes due to Abrams, Ghrist & Peterson. State complexes represent all possible configurations of a system as a single geometric space, thus making them conducive to study using geometric, topological, or combinatorial methods. The main contribution of this work is a modification to the original Abrams, Ghrist & Peterson setup which we introduce to capture agent braiding and thereby more naturally represent the topology of gridworlds. With this modification, the state complexes may exhibit geometric defects (failure of Gromov's Link Condition). Serendipitously, we discover these failures occur exactly where undesirable or dangerous states appear in the gridworld. Our results therefore provide a novel method for seeking guaranteed safety limitations in discrete task environments with single or multiple agents and offer useful safety information (in geometric and topological forms) for incorporation in or analysis of machine learning systems. More broadly, our work introduces tools from geometric group theory and combinatorics to the AI community and demonstrates a proofofconcept for this geometric viewpoint of the task domain through the example of simple gridworld environments.

1:30  3:00 pm EDTTopology + Neuroscience Working GroupsGroup Work  10th Floor Classroom

3:00  3:30 pm EDTCoffee Break11th Floor Collaborative Space
Monday, September 18, 2023

8:50  9:00 am EDTWelcome11th Floor Lecture Hall
 Session Chair
 Brendan Hassett, ICERM/Brown University

9:00  9:45 am EDTNeural dynamics on sparse networks—pruning, error correction, and signal reconstruction11th Floor Lecture Hall
 Speaker
 Rishidev Chaudhuri, University of California, Davis
 Session Chair
 Carina Curto, The Pennsylvania State University
Abstract
Many networks in the brain are sparsely connected, and the brain eliminates connections during development and learning. This talk will focus on questions related to computation and dynamics on these sparse networks. We will first focus on pruning redundant network connections while preserving dynamics and function. In a recurrent network, determining the importance of a connection between two neurons is a difficult computational problem, depending on the role that both neurons play and on all possible pathways of information flow between them. Noise is ubiquitous in neural systems, and often considered an irritant to be overcome. We suggest that noise could instead play a functional role in pruning, allowing the brain to probe network structure and determine which connections are redundant. We construct a simple, local, unsupervised rule that either strengthens or prunes synapses using only connection weight and the noisedriven covariance of the neighboring neurons. For a subset of linear and rectifiedlinear networks, we adapt matrix concentration of measure arguments from the field of graph sparsification to prove that this rule preserves the spectrum of the original matrix and hence preserves network dynamics even when the fraction of pruned connections asymptotically approaches 1. The plasticity rule is biologicallyplausible and may suggest a new role for noise in neural computation. Time permitting, we will then discuss the application of sparse expander graphs to modeling dynamics on neural networks. Expander graphs combine the seemingly contradictory properties of being sparse and wellconnected. Among other remarkable properties, they allow efficient communication, credit assignment and error correction with simple greedy dynamical rules. We suggest that these applications might provide new ways of thinking about neural dynamics, and provide several proofs of principle.

10:00  10:15 am EDTCoffee Break11th Floor Collaborative Space

10:15  11:00 am EDTLocal breakdown of the balance of excitation and inhibition accounts for divisive normalization11th Floor Lecture Hall
 Speaker
 Yashar Ahmadian, Cambridge University
 Session Chair
 Carina Curto, The Pennsylvania State University
Abstract
Excitatory and inhibitory (E & I) inputs to cortical neurons remain balanced across different conditions. This is captured in the balanced network model in which neural populations dynamically adjust their rates to yield tightly balanced E and I inputs and a state in which all neurons are active at levels observed in cortex. But global tight EI balance predicts linear stimulus dependence for population responses, and does not account for systematic cortical response nonlinearities such as divisive normalization, a canonical brain computation. However, when necessary connectivity conditions for global balance fail, states arise in which a subset of neurons are inhibition dominated and inactive. Here, we show analytically that the emergence of such localized balance states robustly leads to normalization, including sublinear integration and winnertakeall behavior. An alternative model that exhibits normalization is the Stabilized Supralinear Network (SSN), in which the EI balance is generically loose, but becomes tight asymptotically for strong inputs. However, an understanding of the causal relationship between EI balance and normalization in SSN are lacking. Here we show that when tight EI balance in the asymptotic, strongly driven regime of SSN is not global, the network does not exhibit normalization at any input strength; thus, in SSN too, significant normalization requires the breakdown of global balance. In summary, we causally and quantitatively connect a fundamental feature of cortical dynamics with a canonical brain computation.

11:15  11:45 am EDTOpen Problems DiscussionProblem Session  11th Floor Lecture Hall
 Session Chairs
 Carina Curto, The Pennsylvania State University
 Katie Morrison, University of Northern Colorado

11:45 am  1:30 pm EDTLunch/Free Time

1:30  2:15 pm EDTDiscovering dynamical patterns of activity from singletrial neural data11th Floor Lecture Hall
 Speaker
 Rodica Curtu, The University of Iowa
 Session Chair
 Carina Curto, The Pennsylvania State University
Abstract
In this talk I will discuss a datadriven method that leverages timedelayed coordinates, diffusion maps, and dynamic mode decomposition, to identify neural features in large scale brain recordings that correlate with subjectreported perception. The method captures the dynamics of perception at multiple timescales and distinguishes attributes of neural encoding of the stimulus from those encoding the perceptual states. Our analysis reveals a set of latent variables that exhibit alternating dynamics along a lowdimensional manifold, like trajectories of attractorbased models. I will conclude by proposing a phaseamplitudecouplingbased model that illustrates the dynamics of data.

2:30  2:35 pm EDTSynaptic mechanisms for resisting distractors in neural fieldsLightning Talks  11th Floor Lecture Hall
 Speaker
 Heather Cihak, University of Colorado Boulder
 Session Chair
 Carina Curto, The Pennsylvania State University
Abstract
Persistent neural activity has been observed in the nonhuman primate cortex when making delayed estimates. Organized activity patterns according to cell feature preference reveals "bumps" that represent analog variables during the delay. Continuum neural field models support bump attractors whose stochastic dynamics can be linked to response statistics (estimate bias and error). Models often ignore the distinct dynamics of bumps in both excitatory/inhibitory population activity, but recent neural and behavioral recordings suggest both play a role in delayed estimate codes and responses. In past work, we developed new methods in asymptotic and multiscale analyses for stochastic and spatiotemporal systems to understand how network architecture determines bump dynamics in networks with distinct E/I populations and short term plasticity. The inhibitory bump dynamics as well as facilitation and diffusion impact the stability and wandering motion of the excitatory bump. Our current work moves beyond studying ensemble statistics like variance to examine potential mechanisms underlying the robustness of working memory to distractors (irrelevant information) presented during the maintenance period wherein the relative timescales of the E/I populations, synaptic vs activity dynamics, as well as short term plasticity may play an important role.

2:35  2:40 pm EDTConvex optimization of recurrent neural networks for rapid inference of neural dynamicsLightning Talks  11th Floor Lecture Hall
 Speaker
 Fatih Dinc, Stanford University
 Session Chair
 Carina Curto, The Pennsylvania State University
Abstract
Advances in optical and electrophysiological recording technologies have made it possible to record the dynamics of thousands of neurons, opening up new possibilities for interpreting and controlling large neural populations. A promising way to extract computational principles from these large datasets is to train dataconstrained recurrent neural networks (dRNNs). However, existing training algorithms for dRNNs are inefficient and have limited scalability, making it a challenge to analyze large neural recordings even in offline scenarios. To address these issues, we introduce a training method termed Convex Optimization of Recurrent Neural Networks (CORNN). In studies of simulated recordings of hundreds of cells, CORNN attained training speeds ~ 100fold faster than traditional optimization approaches while maintaining or enhancing modeling accuracy. We further validated CORNN on simulations with thousands of cells that performed simple computations such as those of a 3bit flipflop or the execution of a timed response. Finally, we showed that CORNN can robustly reproduce network dynamics and underlying attractor structures despite mismatches between generator and inference models, severe subsampling of observed neurons, or mismatches in neural timescales. Overall, by training dRNNs with millions of parameters in subminute processing times on a standard computer, CORNN constitutes a first step towards realtime network reproduction constrained on largescale neural recordings and a powerful computational tool for advancing the understanding of neural computation. My talk focuses on how dRNNs enabled by CORNN can help us reverse engineer the neural code in the mammalian brain.

2:40  2:45 pm EDTRecall tempo of Hebbian sequences depends on the interplay of Hebbian kernel with tutor signal timingLightning Talks  11th Floor Lecture Hall
 Speaker
 Matthew Farrell, Harvard University
 Session Chair
 Carina Curto, The Pennsylvania State University
Abstract
Understanding how neural circuits generate sequential activity is a longstanding challenge. While foundational theoretical models have shown how sequences can be stored as memories with Hebbian plasticity rules, these models considered only a narrow range of Hebbian rules. In this talk I introduce a model for arbitrary Hebbian plasticity rules, capturing the diversity of spiketimingdependent synaptic plasticity seen in experiments, and show how the choice of these rules and of neural activity patterns influences sequence memory formation and retrieval. In particular, I will present a general theory that predicts the speed of sequence replay. This theory lays a foundation for explaining how cortical tutor signals might give rise to motor actions that eventually become ``automatic''. This theory also captures the impact of changing the speed of the tutor signal. Beyond shedding light on biological circuits, this theory has relevance in artificial intelligence by laying a foundation for frameworks whereby slow and computationally expensive deliberation can be stored as memories and eventually replaced by inexpensive recall.

2:45  2:50 pm EDTModeling human temporal EEG responses subject to VR visual stimuliLightning Talks  11th Floor Lecture Hall
 Speaker
 Richard Foster, Virginia Commonwealth University
 Session Chair
 Carina Curto, The Pennsylvania State University
Abstract
When subject to visual stimuli flashing at a constant temporal frequency, it is wellknown that the EEG response has a sharp peak in the power spectrum at the driving frequency. But the EEG response with random frequency stimuli and corresponding biophysical mechanisms are largely unknown. We present a phenomenological model framework in hopes of eventually capturing these EEG responses and unveiling the biophysical mechanisms. Based on observed heterogeneous temporal frequency selectivity curves in V1 cells (Hawken et al. ‘96, Camillo et al ‘20, Priebe et al. ‘06), we endow individual units with these response properties. Preliminary simulation results show that particular temporal frequency selectivity curves can be more indicative of the EEG response. Future directions include the construction of network architecture with interacting units to faithfully model the EEG response.

2:50  2:55 pm EDTRNNs of RNNs: Recursive Construction of Stable Assemblies of Recurrent Neural NetworksLightning Talks  11th Floor Lecture Hall
 Speaker
 Leo Kozachkov, Massachusetts Institute of Technology
 Session Chair
 Carina Curto, The Pennsylvania State University
Abstract
Recurrent neural networks (RNNs) are widely used throughout neuroscience as models of local neural activity. Many properties of single RNNs are well characterized theoretically, but experimental neuroscience has moved in the direction of studying multiple interacting areas, and RNN theory needs to be likewise extended. We take a constructive approach towards this problem, leveraging tools from nonlinear control theory and machine learning to characterize when combinations of stable RNNs will themselves be stable. Importantly, we derive conditions which allow for massive feedback connections between interacting RNNs. We parameterize these conditions for easy optimization using gradientbased techniques, and show that stabilityconstrained "networks of networks" can perform well on challenging sequentialprocessing benchmark tasks. Altogether, our results provide a principled approach towards understanding distributed, modular function in the brain.

3:15  3:45 pm EDTCoffee Break11th Floor Collaborative Space

3:45  4:30 pm EDTUniversal Properties of Strongly Coupled Recurrent Networks11th Floor Lecture Hall
 Speaker
 Robert Rosenbaum, University of Notre Dame
 Session Chair
 Carina Curto, The Pennsylvania State University
Abstract
Balanced excitation and inhibition is widely observed in cortex. How does this balance shape neural computations and stimulus representations? This question is often studied using computational models of neuronal networks in a dynamically balanced state. But balanced network models predict a linear relationship between stimuli and population responses. So how do cortical circuits implement nonlinear representations and computations? We show that every balanced network architecture admits stimuli that break the balanced state and these breaks in balance push the network into a “semibalanced state” characterized by excess inhibition to some neurons, but an absence of excess excitation. The semibalanced state produces nonlinear stimulus representations and nonlinear computations, is unavoidable in networks driven by multiple stimuli, is consistent with cortical recordings, and has a direct mathematical relationship to artificial neural networks.

4:30  6:00 pm EDTReception11th Floor Collaborative Space
Tuesday, September 19, 2023

9:00  9:45 am EDTMultilayer Networks in Neuroscience11th Floor Lecture Hall
 Speaker
 Mason Porter, UCLA
 Session Chair
 Brent Doiron, University of Chicago
Abstract
I will discuss multilayer networks in neuroscience. I will introduce the idea of multilayer networks and discuss some uses of multilayer networks in dneuroscience. I will present some interesting challenges.

10:00  10:15 am EDTCoffee Break11th Floor Collaborative Space

10:15  11:00 am EDTState modulation in spatial networks of multiple interneuron subtypes11th Floor Lecture Hall
 Speaker
 Chengcheng Huang, University of Pittsburgh
 Session Chair
 Brent Doiron, University of Chicago
Abstract
Neuronal responses to sensory stimuli can be strongly modulated by animal's brain state. Three distinct subtypes of inhibitory interneurons, parvalbumin (PV), somatostatin (SOM), and vasoactive intestinal peptide (VIP) expressing cells, have been identified as key players of flexibly modulating network activity. The three interneuron populations have specialized local microcircuit motifs and are targeted differentially by neuromodulators and topdown inputs from higherorder cortical areas. In this work, we systematically study the function of each interneuron cell type at modulating network dynamics in a spatially ordered spiking neuron network. We analyze the changes in firing rates and network synchrony as we apply static current to each cell population. We find that the modulation pattern by activating E or PV cells is distinct from that by activating SOM or VIP cells. In particular, we identify SOM cells as the main driver of network synchrony.

11:15  11:45 am EDTOpen Problems DiscussionProblem Session  11th Floor Lecture Hall
 Session Chairs
 Brent Doiron, University of Chicago
 Zachary Kilpatrick, University of Colorado Boulder

11:50 am  12:00 pm EDTGroup Photo (Immediately After Talk)11th Floor Lecture Hall

12:00  1:30 pm EDTWorking Lunch11th Floor Collaborative Space

1:30  2:15 pm EDTPlasticity in balanced neuronal networks11th Floor Lecture Hall
 Speaker
 Kresimir Josic, University of Houston
 Session Chair
 Brent Doiron, University of Chicago
Abstract
I will first describe how to extend the theory of balanced networks to account for synaptic plasticity. This theory can be used to show when a plastic network will maintain balance, and when it will be driven into an unbalanced state. I will next discuss how this approach provides evidence for a novel form of rapid compensatory inhibitory plasticity using experimental evidence obtained using optogenetic activation of excitatory neurons in primate visual cortex (area V1). The theory explains how such activation induces a populationwide dynamic reduction in the strength of neuronal interactions over the timescale of minutes during the awake state, but not during rest. I will shift gears in the final part of the talk, and discuss how community detection algorithms can help uncover the large scale organization of neuronal networks from connectome data, using the Drosophila hemibrain dataset as an example.

2:35  2:40 pm EDTQPhase reduction of multidimensional stochastic OrnsteinUhlenbeck process networksLightning Talks  11th Floor Lecture Hall
 Speaker
 Maxwell Kreider, Case Western Reserve University
 Session Chair
 Brent Doiron, University of Chicago
Abstract
Phase reduction is an effective tool to study the network dynamics of deterministic limitcycle oscillators. The recent introduction of stochastic phase concepts allows us to extend these tools to stochastic oscillators; of particular utility is the asymptotic stochastic phase, derived from the eigenfunction decomposition of the system's probability density. Here, we study networks of coupled oscillatory twodimensional OrnsteinUhlenbeck processes (OUPs) with complex eigenvalues. We characterize system dynamics by providing an exact expression for the asymptotic stochastic phase for OUP networks of any dimension and arbitrary coupling structure. Furthermore, we introduce an order parameter quantifying the synchrony of networks of stochastic oscillators, and apply it to our OUP model. We argue that the OUP network provides a new, analytically tractable approach to analysis of large scale electrophysiological recordings.

2:40  2:45 pm EDTFeedback Controllability as a Normative Theory of Neural DynamicsLightning Talks  11th Floor Lecture Hall
 Speaker
 Ankit Kumar, UC Berkeley
 Session Chair
 Brent Doiron, University of Chicago
Abstract
Brain computations emerge from the collective dynamics of distributed neural populations. Behaviors including reaching and speech are explained by principles of optimal feedback control, yet if and how this normative description shapes neural population dynamics is unknown. We created dimensionality reduction methods that identify subspaces of dynamics that are most feedforward controllable (FFC) vs. feedback controllable (FBC). We show that FBC and FFC subspaces diverge for dynamics generated by nonnormal connectivity. In neural recordings from monkey M1 and S1 during reaching, FBC subspaces are better decoders of reach velocity, particularly during reach acceleration, and that FBC provides a first principles account of the observation of rotational dynamics. Overall, our results demonstrate feedback controllability is a novel, normative theory of neural population dynamics, and reveal how the structure of high dynamical systems shape their ability to be controlled.

2:45  2:50 pm EDTAdaptive whitening with fast gain modulation and slow synaptic plasticityLightning Talks  11th Floor Lecture Hall
 Speaker
 David Lipshutz, Flatiron Institute
 Session Chair
 Brent Doiron, University of Chicago
Abstract
Neurons in early sensory areas rapidly adapt to changing sensory statistics, both by normalizing the variance of their individual responses and by reducing correlations between their responses. Together, these transformations may be viewed as an adaptive form of statistical whitening. In this talk, I will present a normative multitimescale mechanistic model of adaptive whitening with complementary computational roles for gain modulation and synaptic plasticity. Gains are modified on a fast timescale to adapt to the current statistical context, whereas synapses are modified on a slow timescale to learn structural properties of the input statistics that are invariant across contexts.

2:50  2:55 pm EDTThe combinatorial code and the graph rules of Dale networksLightning Talks  11th Floor Lecture Hall
 Speaker
 Nikola Milicevic, Pennsylvania State University
 Session Chair
 Brent Doiron, University of Chicago
Abstract
We describe the combinatorics of equilibria and steady states of neurons in thresholdlinear networks that satisfy the Dale’s law. The combinatorial code of a Dale network is characterized in terms of two conditions: (i) a condition on the network connectivity graph, and (ii) a spectral condition on the synaptic matrix. We find that in the weak coupling regime the combinatorial code depends only on the connectivity graph, and not on the particulars of the synaptic strengths. Moreover, we prove that the combinatorial code of a weakly coupled network is a sublattice, and we provide a learning rule for encoding a sublattice in a weakly coupled excitatory network. In the strong coupling regime we prove that the combinatorial code of a generic Dale network is intersectioncomplete and is therefore a convex code, as is common in some sensory systems in the brain.

2:55  3:00 pm EDTDecomposed Linear Dynamical Systems for Studying Inter and IntraRegion Neural DynamicsLightning Talks  11th Floor Lecture Hall
 Speaker
 Noga Mudrik, The Johns Hopkins University
 Session Chair
 Brent Doiron, University of Chicago
Abstract
Understanding the intricate relationship between recorded neural activity and behavior is a pivotal pursuit in neuroscience. However, existing models frequently overlook the nonlinear and nonstationary behavior evident in neural data, opting instead to center their focus on simplified projections or overt dynamical systems. We introduce a Decomposed Linear Dynamical Systems (dLDS) approach to capture these complex dynamics by representing them as a sparse timevarying linear combination of interpretable linear dynamical components. dLDS is trained using an expectation maximization procedure where the obscured dynamical components are iteratively inferred using dictionary learning. This approach enables the identification of overlapping circuits, while the sparsity applied during the training maintains the model interpretability. We demonstrate that dLDS successfully recovers the underlying linear components and their timevarying coefficients in both synthetic and neural data examples, and show that it can learn efficient representations of complex data. By leveraging the rich data from the International Brain Laboratory’s Brain Wide Map dataset, we extend dLDS to model communication among ensembles within and between brain regions, drawing insights from multiple nonsimultaneous recording sessions.

3:00  3:05 pm EDTCharacterizing Neural Spike Train Data for Chemosensory Coding AnalysisLightning Talks  11th Floor Lecture Hall
 Speaker
 Audrey Nash, Florida State University
 Session Chair
 Brent Doiron, University of Chicago
Abstract
In this presentation, we explore neural spike train data to discern a neuron's ability to distinguish between various stimuli. By examining both the spiking rate and the temporal distribution of spikes (phase of spiking), we aim to unravel the intricacies of chemosensory coding in neurons. We will provide a concise overview of our methodology for identifying chemosensory coding neurons and delve into the application of metricbased analysis techniques in conjunction with optimal transport methods. This combined approach allows us to uncover emerging patterns in tastant coding across multiple neurons and quantify the respective impacts of spiking rate and temporal phase in taste decoding.

3:05  3:10 pm EDTInfinitedimensional Dynamics in a Model of EEG Activity in the NeocortexLightning Talks  11th Floor Lecture Hall
 Speaker
 Farshad Shirani, Georgia Institute of Technology
 Session Chair
 Brent Doiron, University of Chicago
Abstract
I present key analytical and computational results on a mean field model of electroencephalographic activity in the neocortex, which is composed of a system of coupled ODEs and PDEs. I show that for some sets of biophysical parameter values the equilibrium set of the model is not compact, which further implies that the global attracting set of the model is infinitedimensional. I also present computational results on generation and spatial propagation of transient gamma oscillations in the solutions of the model. The results identify important challenges in interpreting and modelling the temporal pattern of EEG recordings, caused by low spatial resolution of EEG electrodes.

3:10  3:15 pm EDTWhat is the optimal topology of setwise connections for a memory network?Lightning Talks  11th Floor Lecture Hall
 Speaker
 Thomas Burns, ICERM
 Session Chair
 Brent Doiron, University of Chicago
Abstract
Simplicial Hopfield networks (Burns & Fukai, 2023) explicitly model setwise connections between neurons based on a simplicial complex to store memory patterns. Randomly diluted networks  where only a randomly chosen fraction of the simplices, i.e., setwise connections, have nonzero weights  show performance above traditional associative memory networks with only pairwise connections between neurons but the same total number of nonzero weighted connections. However, could there be a cleverer choice of connections to weight given known memory patterns we want to store? I suspect so, and in this talk I will to formally pose the problem for others to consider.

3:30  4:00 pm EDTCoffee Break11th Floor Collaborative Space

4:00  4:45 pm EDTReliability and robustness of oscillations in some slowfast chaotic systems11th Floor Lecture Hall
 Speaker
 Jonathan Jaquette, New Jersey Institute of Technology
 Session Chair
 Brent Doiron, University of Chicago
Abstract
A variety of nonlinear models of biological systems generate complex chaotic behaviors that contrast with biological homeostasis, the observation that many biological systems prove remarkably robust in the face of changing external or internal conditions. Motivated by the subtle dynamics of cell activity in a crustacean central pattern generator, we propose a refinement of the notion of chaos that reconciles homeostasis and chaos in systems with multiple timescales. We show that systems displaying relaxation cycles going through chaotic attractors generate chaotic dynamics that are regular at macroscopic timescales, thus consistent with physiological function. We further show that this relative regularity may break down through global bifurcations of chaotic attractors such as crises, beyond which the system may generate erratic activity also at slow timescales. We analyze in detail these phenomena in the chaotic Rulkov map, a classical neuron model known to exhibit a variety of chaotic spike patterns. This leads us to propose that the passage of slow relaxation cycles through a chaotic attractor crisis is a robust, general mechanism for the transition between such dynamics, and we validate this numerically in other models.

5:30  7:00 pm EDTNetworking event with Carney Institute for Brain ScienceExternal Event  Carney Institute for Brain Science  164 Angell St, Providence RI, 02906
Wednesday, September 20, 2023

9:00  9:45 am EDTModeling in neuroscience: the challenges of biological realism and computability11th Floor Lecture Hall
 Speaker
 LaiSang Young, Courant Institute
 Session Chair
 Katie Morrison, University of Northern Colorado
Abstract
Biologically realistic models of the brain have the potential to offer insight into neural mechanisms; they have predictive power, the ultimate goal of biological modeling. These benefits, however, come at considerable costs: network models that involve hundreds of thousands of neurons and many (unknown) parameters are unwieldy to build and to test, let alone to simulate and to analyze. Reduced models have obvious advantages, but the farther removed from biology a model is, the harder it is to draw meaningful inferences. In this talk, I propose a modeling strategy that aspires to be both realistic and computable. Two crucial ingredients are (i) we track neuronal dynamics on two spatial scales: coarsegrained dynamics informed by local activity, and (ii) we compute a family of potential local responses in advance, eliminating the need to perform similar computations at each spatial location in each update. I will illustrate this computational strategy using a model of the monkey visual cortex, which is very similar to that of humans.

10:00  10:15 am EDTCoffee Break11th Floor Collaborative Space

10:15  11:00 am EDTUncertainty Quantification for Neurobiological Networks.11th Floor Lecture Hall
 Speaker
 Daniele Avitabile, Vrije Universiteit Amsterdam
 Session Chair
 Katie Morrison, University of Northern Colorado
Abstract
This talk presents a framework for forward uncertainty quantification problems in spatiallyextended neurobiological networks. We will consider networks in which the cortex is represented as a continuum domain, and local neuronal activity evolves according to an integrodifferential equation, collecting inputs nonlocally, from the whole cortex. These models are sometimes referred to as neural field equations. Largescale brain simulations of such models are currently performed heuristically, and the numerical analysis of these problems is largely unexplored. In the first part of the talk I will summarise recent developments for the rigorous numerical analysis of projection schemes for deterministic neural fields, which sets the foundation for developing FiniteElement and Spectral schemes for largescale problems. The second part of the talk will discuss the case of networks in the presence of uncertainties modelled with random data, in particular: random synaptic connections, external stimuli, neuronal firing rates, and initial conditions. Such problems give rise to random solutions, whose mean, variance, or other quantities of interest have to be estimated using numerical simulations. This socalled forward uncertainty quantification problem is challenging because it couples spatially nonlocal, nonlinear problems to largedimensional random data. I will present a family of schemes that couple a spatial projector for the spatial discretisation, to stochastic collocation for the random data. We will analyse the time dependent problem with random data and the schemes from a functional analytic viewpoint, and show that the proposed methods can achieve spectral accuracy, provided the random data is sufficiently regular. We will showcase the schemes using several examples. Acknowledgements This talk presents joint work with Francesca Cavallini (VU Amsterdam), Svetlana Dubinkina (VU Amsterdam), and Gabriel Lord (Radboud University).

11:15 am  12:00 pm EDTOpen Problems DiscussionProblem Session  11th Floor Lecture Hall
 Session Chairs
 Konstantin Mischaikow, Rutgers University
 Katie Morrison, University of Northern Colorado

12:00  2:00 pm EDTLunch/Free Time

2:00  2:45 pm EDTDynamics of stochastic integrateandfire networks11th Floor Lecture Hall
 Speaker
 Gabe Ocker, Boston University
 Session Chair
 Katie Morrison, University of Northern Colorado

3:00  3:05 pm EDTA Step Towards Uncovering The Structure of Multistable Neural NetworksLightning Talks  11th Floor Lecture Hall
 Speaker
 Magnus Tournoy, Flatiron Institute
 Session Chair
 Katie Morrison, University of Northern Colorado
Abstract
With the experimental advances in the recording of large populations of neurons, theorists are in the humbling position of making sense of a staggering amount of data. One question that will become more into reach is how network structure relates to function. But going beyond explanatory models and becoming more predictive will require a fundamental approach. In this talk we’ll take the view of a physicist and formulate exact results within a simple, yet general, toy model called Glass networks. Named after its originator Leon Glass, they are the infinite gain limit of wellknown circuit models like continuoustime Hopfield networks. We’ll show that, within this limit, stability conditions reduce to semipositivity constraints on the synaptic weight matrix. Having a clear link between structure and function in possession, the consequences of multistability on the network architecture can be explored. One finding is the factorization of the weight matrix in terms of nonnegative matrices. Interestingly this factorization completely identifies the existence of stable states. Another result is the reduction of allowed sign patterns for the connections. A consequence hereof are lower bounds on the number of excitatory and inhibitory connections. At last we will discuss the special case of “sign stability”, where stability is guaranteed by the topology of the network. Derivations of these results will be supplemented by a number of examples.

3:05  3:10 pm EDTClustering and Distribution of the Adaptation VariableLightning Talks  11th Floor Lecture Hall
 Speaker
 Ka Nap Tse, University of Pittsburgh
 Session Chair
 Katie Morrison, University of Northern Colorado
Abstract
Brain wave is an important phenomenon in neuroscience. Besides synchronous spiking, excitatory cells with adaptation can spike in clusters to cause a rhythmic activity of the network. In previous works, the adaptation variable is usually eliminated for further analysis. In this talk, a way to study this clustering behaviour through the evolution of the distribution of the adaptation variable will be discussed. We then transform the distribution to the timetospike coordinate for further explorations.

3:10  3:15 pm EDTLowdimensional manifold of neural oscillations revealed by datadriven model reductionLightning Talks  11th Floor Lecture Hall
 Speaker
 ZhuoCheng Xiao, New York University
 Session Chair
 Katie Morrison, University of Northern Colorado
Abstract
Neural oscillations across various frequency bands are believed to underlie essential brain functions, such as information processing and cognitive activities. However, the emergence of oscillatory dynamics from spiking neuronal networks—and the interplay among different cortical rhythms—has seldom been theoretically explored, largely due to the strong nonlinearity and high dimensionality involved. To address this challenge, we have developed a series of datadriven model reduction methods tailored for spiking network dynamics. In this talk I will present nearly twodimensional manifolds in the reduced coordinates that successfully capture the emergence of gamma oscillations. Specifically, we find that the initiation phases of each oscillation cycle are the most critical. Subsequent cycles are more deterministic and lie on the aforementioned twodimensional manifold. The Poincaré mappings between these initiation phases reveal the structure of the dynamical system and successfully explain the bifurcation from gamma oscillations to multiband oscillations.

3:15  3:20 pm EDTSensitivity to control signals in triphasic rhythmic neural systems: a comparative mechanistic analysis via infinitesimal local timing response curvesLightning Talks  11th Floor Lecture Hall
 Speaker
 Zhuojun Yu, Case Western Reserve University
 Session Chair
 Katie Morrison, University of Northern Colorado
Abstract
Similar activity patterns may arise from model neural networks with distinct coupling properties and individual unit dynamics. These similar patterns may, however, respond differently to parameter variations and, specifically, to tuning of inputs that represent control signals. In this work, we analyze the responses resulting from modulation of a localized input in each of three classes of model neural networks that have been recognized in the literature for their capacity to produce robust threephase rhythms: coupled fastslow oscillators, nearheteroclinic oscillators, and thresholdlinear networks. Triphasic rhythms, in which each phase consists of a prolonged activation of a corresponding subgroup of neurons followed by a fast transition to another phase, represent a fundamental activity pattern observed across a range of central pattern generators underlying behaviors critical to survival, including respiration, locomotion, and feeding. To perform our analysis, we extend the recently developed local timing response curve (lTRC), which allows us to characterize the timing effects due to perturbations, and we complement our lTRC approach with modelspecific dynamical systems analysis. Interestingly, we observe disparate effects of similar perturbations across distinct model classes. Thus, this work provides an analytical framework for studying control of oscillations in nonlinear dynamical systems, and may help guide model selection in future efforts to study systems exhibiting triphasic rhythmic activity.

3:20  3:25 pm EDTModeling the effects of celltype specific lateral inhibitionLightning Talks  11th Floor Lecture Hall
 Speaker
 Soon Ho Kim, Georgia Institute of Technology
 Session Chair
 Katie Morrison, University of Northern Colorado

3:30  4:00 pm EDTCoffee Break11th Floor Collaborative Space

4:00  4:45 pm EDTComputing the Global Dynamics of Parameterized Families of ODEs11th Floor Lecture Hall
 Speaker
 Marcio Gameiro, Rutgers University
 Session Chair
 Katie Morrison, University of Northern Colorado
Abstract
We present a combinatorial topological method to compute the dynamics of a parameterized family of ODEs. A discretization of the state space of the systems is used to construct a combinatorial representation from which recurrent versus nonrecurrent dynamics is extracted. Algebraic topology is then used to validate and characterize the dynamics of the system. We will discuss the combinatorial description and the algebraic topological computations and will present applications to systems of ODEs arising from gene regulatory networks.
Thursday, September 21, 2023

9:00  9:45 am EDTMultiple timescale respiratory dynamics and effect of neuromodulation11th Floor Lecture Hall
 Speaker
 Yangyang Wang, Brandeis University
 Session Chair
 Zachary Kilpatrick, University of Colorado Boulder
Abstract
Respiration is an involuntary process in all living beings required for our survival. The preBötzinger complex (preBötC) in the mammalian brainstem is a neuronal network that drives inspiratory rhythmogenesis, whose activity is constantly modulated by neuromodulators in response to changes in the environment. In this talk, we will discuss chanllenges involved in the analysis of bursting dynamics in preBötC neurons and how these dynamics change during prenatal development. We will also combine insights from in vitro recordings and dynamical systems modeling to investigate the effect of norepinephrine (NE), an excitatory neuromodulator, on respiratory dynamics. Our investigation employs bifurcation analysis to reveal the mechanisms by which NE differentially modulates different types of preBötC bursting neurons.

10:00  10:30 am EDTCoffee Break11th Floor Collaborative Space

10:30  11:15 am EDTEnhancing Neuronal Classification Capacity via Nonlinear Parallel Synapses11th Floor Lecture Hall
 Speaker
 Marcus Benna, UC San Diego
 Session Chair
 Zachary Kilpatrick, University of Colorado Boulder
Abstract
We discuss models of a neuron that has multiple synaptic contacts with the same presynaptic axon. We show that a diverse set of learned nonlinearities in these parallel synapses leads to a substantial increase in the neuronal classification capacity.

11:30 am  1:30 pm EDTWorking Lunch: Open Problems SessionWorking Lunch  11th Floor Collaborative Space

1:30  2:15 pm EDTCombinatorial structure of continuous dynamics in gene regulatory networks11th Floor Lecture Hall
 Speaker
 Tomas Gedeon, Montana State University
 Session Chair
 Zachary Kilpatrick, University of Colorado Boulder
Abstract
Gene network dynamics and neural network dynamics face similar challenges of high dimensionality of both phase space and parameter space, and a lack of reliable experimental data to infer parameters. We first describe the mathematical foundation of DSGRN (Dynamic Signatures Generated by Regulatory Networks), an approach that provides a combinatorial description of global dynamics of a network over its parameter space. Finite description allows comparison of parameterized dynamics between hundreds of networks to discard networks that are not compatible with experimental data. We also describe a close connection of DSGRN to Boolean network models that allows us to view DSGRN as a connection between parameterized continuous time dynamics and discrete dynamics of Boolean modets. If time allows, we discuss several applications of this methodology to systems biology.

2:30  3:15 pm EDTA model of the mammalian neural motor architecture elucidates the mechanisms underlying efficient and flexible control of network dynamics11th Floor Lecture Hall
 Speaker
 Laureline Logiaco, Massachusetts Institute of Technology
 Session Chair
 Zachary Kilpatrick, University of Colorado Boulder
Abstract
One of the fundamental functions of the brain is to flexibly plan and control movement production at different timescales in order to efficiently shape structured behaviors. I will present research investigating how these complex computations are performed in the mammalian brain, with an emphasis on autonomous motor control. Specifically, I will focus on the mechanisms supporting efficient interfacing between 'higherlevel' planning commands and 'lowerlevel' motor cortical dynamics that ultimately drive muscles. I will take advantage of the fact that the anatomy of the circuits underlying motor control is well known. It notably involves the primary motor cortex, a recurrent network that generates learned commands to drive muscles while interacting through loops with thalamic neurons that lack recurrent excitation. Using an analytically tractable model that incorporates these architectural constraints, I will explain how this motor circuit can implement a form of efficient modularity by combining (i) plastic thalamocortical loops that are movementspecific and (ii) shared hardwired circuits. I will show that this modular architecture can balance two different objectives: first, supporting the flexible recombination of an extensible library of reusable motor primitives; and second, promoting the efficient use of neural resources by taking advantage of shared connections between modules. I will end by mentioning some open avenues for further mathematical analyses related to this framework.

3:30  4:00 pm EDTCoffee Break11th Floor Collaborative Space

4:00  4:45 pm EDTLowrank neural connectivity for the discrimination of temporal patterns.11th Floor Lecture Hall
 Speaker
 Sean Escola, Columbia University
 Session Chair
 Zachary Kilpatrick, University of Colorado Boulder
Friday, September 22, 2023

9:00  9:45 am EDTMeanfield theory of learning dynamics in deep neural networks11th Floor Lecture Hall
 Speaker
 Cengiz Pehlevan, Harvard University
 Session Chair
 Konstantin Mischaikow, Rutgers University
Abstract
Learning dynamics of deep neural networks is complex. While previous approaches made advances in mathematical analysis of the dynamics of twolayer neural networks, addressing deeper networks have been challenging. In this talk, I will present a mean field theory of the learning dynamics of deep networks and discuss its implications.

10:00  10:45 am EDTMultilevel measures for understanding and comparing biological and artificial neural networks11th Floor Lecture Hall
 Speaker
 SueYeon Chung, New York University
 Session Chair
 Konstantin Mischaikow, Rutgers University
Abstract
I will share recent theoretical advances on how representation's population level properties such as highdimensional geometries and spectral properties can be used to capture (1) the classification capacity of neural manifolds, and (2) prediction error of neural data from network model representations.

11:00  11:30 am EDTCoffee Break11th Floor Collaborative Space

11:30 am  12:15 pm EDTA Sparsecoding Model of Categoryspecific Functional Organization in IT Cortex11th Floor Lecture Hall
 Speaker
 Demba Ba, Harvard University
 Session Chair
 Konstantin Mischaikow, Rutgers University
Abstract
Primary sensory areas in the brain of mammals may have evolved to compute efficient representations of natural scenes. In the late 90s, Olhausen and Field proposed a model that expresses the components of a natural scene, e.g. naturalimage patches, as sparse combinations of a common set of patterns. Applied to a dataset of natural images, this socalled sparse coding model learns patterns that resemble the receptive fields of V1 neurons. Recordings from the monkey inferotemporal (IT) cortex suggest the presence, in this region, of a sparse code for naturalimage categories. The recordings also suggest that, physically, IT neurons form spatial clusters, each of which preferentially responds to images from certain categories. Taken together, this evidence suggests that neurons in IT cortex form functional groups that reflect the grouping of natural images into categories. My talk will introduce a new sparsecoding model that exhibits this categorical form of functional grouping.

12:30  2:00 pm EDTLunch/Free Time

2:00  2:45 pm EDTFinal Open Problems DiscussionProblem Session  11th Floor Lecture Hall
 Session Chairs
 Carina Curto, The Pennsylvania State University
 Konstantin Mischaikow, Rutgers University

3:00  3:30 pm EDTCoffee Break11th Floor Collaborative Space
Monday, September 25, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

10:00  11:00 am EDTJournal Club11th Floor Lecture Hall

3:00  3:30 pm EDTCoffee Break11th Floor Collaborative Space

3:30  5:00 pm EDTTLN Working GroupGroup Work  10th Floor Classroom
Tuesday, September 26, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00  10:30 am EDTTutorialTutorial  11th Floor Lecture Hall

3:00  3:30 pm EDTCoffee Break11th Floor Collaborative Space
Wednesday, September 27, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00  10:00 am EDTProfessional Development: Ethics IProfessional Development  11th Floor Lecture Hall

3:00  3:30 pm EDTCoffee Break11th Floor Collaborative Space
Thursday, September 28, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00  10:30 am EDTTutorialTutorial  11th Floor Lecture Hall

12:00  1:30 pm EDTOpen Problems Lunch SeminarWorking Lunch  11th Floor Lecture Hall

3:00  3:30 pm EDTCoffee Break11th Floor Collaborative Space
Friday, September 29, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

11:00  11:30 am EDTRecurrent network models for predictive processingPost Doc/Graduate Student Seminar  10th Floor Classroom
 Bin Wang, University of California, San Diego
Abstract
Predictive responses to sensory stimuli are prevalent across cortical networks and are thought to be important for multisensory and sensorimotor learning. It has been hypothesized that predictive processing relies on computations done by two separate functional classes of cortical neurons: one specialized for “faithful” representation of external stimuli, and another for conveying predictionerror signals. It remains unclear how such predictive representations are formed in natural conditions, where stimuli are highdimensional. In this presentation, I will present some efforts on characterizing how highdimensional predictive processing can be performed through recurrent networks. I will start with the neuroscience motivations, define the mathematical models and mention some related mathematical questions that we haven't yet solved along the way.

11:30 am  12:00 pm EDTFishing for beta: uncovering mechanisms underlying cortical oscillations in largescale biophysical modelsPost Doc/Graduate Student Seminar  10th Floor Classroom
 Nicholas Tolley, Brown University
Abstract
Beta frequency (1330 Hz) oscillations are robustly observed across the neocortex, and are strongly predictive of behavior and disease states. While several theories exist regarding their functional significance, the cell and circuit level activity patterns underlying the generation of beta activity remains uncertain. We approach this problem using the Human Neocortical Neurosolver (HNN; hnn.brown.edu), a detailed biophysical model of a cortical column which simulates the microscale activity patterns underlying macroscale field potentials like beta oscillations. Detailed biophysical models potentially offer concrete and biologically interpretable predictions, but their use is challenged by computationally expensive simulations, an overwhelmingly large parameter space, and highly complex relationships between parameters and model outputs. We demonstrate how these challenges can be overcome by combining HNN with simulation based inference (SBI), a deep learning based Bayesian inference framework, and use it to characterize the space of parameters capable of producing beta oscillations. Specifically, we use the HNNSBI framework to characterize the constraints on network connectivity for producing spontaneous beta. In future work, we plan to compare these predictions to higher level neural models to identify which simplifying assumptions are consistent with detailed models of neural oscillations.

1:30  3:00 pm EDTTopology+Neuro Working GroupGroup Work  10th Floor Classroom

3:00  3:30 pm EDTCoffee Break11th Floor Collaborative Space
Monday, October 2, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

10:00  10:45 am EDTNonlinear stimulus representation in neural circuits with approximate excitatoryinhibitory balanceJournal Club  10th Floor Classroom

3:00  3:30 pm EDTCoffee Break11th Floor Collaborative Space

3:30  5:00 pm EDTTLN Working GroupGroup Work  10th Floor Classroom
Tuesday, October 3, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00  10:30 am EDTComputational topology and network dynamics (Part 1 of 2)Tutorial  10th Floor Classroom
 Marcio Gameiro, Rutgers University
Abstract
We will discuss a combinatorial topological method to compute the dynamics of a network. A discretization of the state space of the systems is used to construct a combinatorial representation from which recurrent versus nonrecurrent dynamics is extracted. This approach is implemented in the DSGRN (Dynamic Signatures Generated by Regulatory Networks) software, which computes a combinatorial description of parameter space and the global dynamics of a network. Algebraic topology (Conley index) is then used to validate and characterize the dynamics of the system. We will discuss the combinatorial description and the algebraic topological computations and will present software to carry out the computations.

3:00  3:30 pm EDTCoffee Break11th Floor Collaborative Space
Wednesday, October 4, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00  10:00 am EDTProfessional Development: Ethics IIProfessional Development  11th Floor Lecture Hall

10:30 am  12:00 pm EDTComputational topology and network dynamics (Part 2 of 2)Tutorial  10th Floor Classroom
 Marcio Gameiro, Rutgers University
Abstract
We will discuss a combinatorial topological method to compute the dynamics of a network. A discretization of the state space of the systems is used to construct a combinatorial representation from which recurrent versus nonrecurrent dynamics is extracted. This approach is implemented in the DSGRN (Dynamic Signatures Generated by Regulatory Networks) software, which computes a combinatorial description of parameter space and the global dynamics of a network. Algebraic topology (Conley index) is then used to validate and characterize the dynamics of the system. We will discuss the combinatorial description and the algebraic topological computations and will present software to carry out the computations.

3:00  3:30 pm EDTCoffee Break11th Floor Collaborative Space

3:30  4:30 pm EDTHuman Necortical Neurosolver: A neural modeling software for multiscale interpretation of human electrophysiology11th Floor Lecture Hall
 Stephanie Jones, Brown Univeristy
Thursday, October 5, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00  10:30 am EDTConvex neural codesTutorial  10th Floor Classroom
 Nora Youngs, Colby College
Abstract
In this tutorial I'll introduce convex neural codes, which are codes that arise from arrangements of convex regions. We will go through some topological, combinatorial, and algebraic methods we have used to study such codes...and also, draw lots of pictures.

12:00  1:30 pm EDTMathematics of Neural Nets: Random Matrices, Multiscale and Stability  Lunch Seminar11th Floor Lecture Hall
 Speaker
 Leonid Berlyand, Penn State
 Session Chair
 Carina Curto, The Pennsylvania State University

3:00  3:30 pm EDTCoffee Break11th Floor Collaborative Space
Friday, October 6, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:30  10:30 am EDT"Something Cool I Know" Seminar10th Floor Classroom

11:00  11:30 am EDTParameter estimation with uncertainty quantification via Markov Chain Monte Carlo methodsPost Doc/Graduate Student Seminar  11th Floor Lecture Hall
 Federica Milinanni, KTH  Royal Institute of Technology

11:30 am  12:00 pm EDTHarmonic Analysis of SequencesPost Doc/Graduate Student Seminar  11th Floor Lecture Hall
 Hannah Santa Cruz, Penn State
Abstract
The Combinatorial Laplacian is a popular tool in Graph and Network analysis. Recent work has proposed the use of Hodge Laplacians and the Magnetic Laplacian to analyze Simplicial Complexes and Directed Graphs respectively. We continue this work, by interpreting the Hodge Laplacian associated to a weighted simplicial complex, in terms of a weight function which is induced by a probability distribution. In particular, we develop a null hypothesis weighted simplicial complex model, induced by an independent distribution on the vertices, and show that the associated Laplacian is trivial. We extend this work to Sequence Complexes, where we consider the faces to be sequences, allowing for repeated vertices and distinguishing sequences with different orderings. In this setting, we also explore the Laplacian associated to a weight function induced by an independent distribution on the vertices, and completely describe it’s eigen spectrum, which is no longer trivial but still simple. Our analysis and findings contribute to the broader field of spectral graph theory and provide a deeper understanding of Laplacians on simplicial and sequence complexes, paving the way for further exploration and applications of Laplacian operators.

1:30  3:00 pm EDTTopology+Neuro Working GroupGroup Work  10th Floor Classroom

3:00  3:30 pm EDTCoffee Break11th Floor Collaborative Space
Monday, October 9, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

10:00  10:45 am EDTFrom the statistics of connectivity to the statistics of spike times in neuronal networksJournal Club  10th Floor Classroom

3:30  5:00 pm EDTTLN Working GroupGroup Work  10th Floor Classroom
Tuesday, October 10, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00  10:30 am EDTTutorial on oriented matroids and neural codesTutorial  10th Floor Classroom
 Alexander Kunin, Creighton University
 Caitlin Lienkaemper, Boston University

3:00  3:30 pm EDT"Ada Lovelace Day" Coffee BreakCoffee Break  11th Floor Collaborative Space
Wednesday, October 11, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00  10:30 am EDTThe cohomology ring and some related persistent invariantsTutorial  10th Floor Classroom
 Ling Zhou, ICERM

3:00  3:30 pm EDTCoffee Break11th Floor Collaborative Space

3:30  4:30 pm EDTNetwork resonance: a framework for dissecting feedback and frequency filtering mechanisms in neuronal systems11th Floor Lecture Hall
 Speaker
 Horacio Rotstein, New Jersey Institute of Technology
 Session Chair
 Peter Thomas, Case Western Reserve University
Abstract
Resonance is defined as a maximal amplification of the response of a system to periodic inputs in a limited, intermediate input frequency band. Resonance may serve to optimize interneuronal communication, and has been observed at multiple levels of neuronal organization including membrane potential fluctuations, single neuron spiking, postsynaptic potentials, and neuronal networks. However, it is unknown how resonance observed at one level of neuronal organization (e.g., network) depends on the properties of the constituting building blocks, and whether, and if yes how, it affects the resonant and oscillatory properties upstream. One difficulty is the absence of a conceptual framework that facilitates the interrogation of resonant neuronal circuits and organizes the mechanistic investigation of network resonance in terms of the circuit components, across levels of organization. We address these issues by discussing a number of representative case studies. The dynamic mechanisms responsible for the generation of resonance involve disparate processes, including negative feedback effects, historydependence, spiking discretization combined with subthreshold passive dynamics, combinations of these, and resonance inheritance from lower levels of organization. The bandpass filters associated with the observed resonances are generated by primarily nonlinear interactions of low and highpass filters. We identify these filters (and interactions) and we argue that these are the constitutive building blocks of a resonance framework. Finally, we discuss alternative frameworks and we show that different types of models (e.g., spiking neural networks and rate models) can show the same type of resonance by qualitative different mechanisms.
Thursday, October 12, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00  10:30 am EDTTutorial on oriented matroids and neural codesTutorial  10th Floor Classroom
 Alexander Kunin, Creighton University
 Caitlin Lienkaemper, Boston University

12:00  1:30 pm EDTOpen Problems Related to the Stochastic Leaky Integrateandfire ModelOpen Problems Seminar  Lunch  11th Floor Lecture Hall
 Gabe Ocker, Boston University

3:00  3:30 pm EDTCoffee Break11th Floor Collaborative Space

3:30  4:30 pm EDTGabor Frames and Contact Geometry in models of the primary visual cortex10th Floor Classroom
 Vasiliki Liontou, ICERM
Abstract
In this talk, I will introduce a model of the primary visual cortex (V1), which allows the compression and decomposition of a signal by a discrete family of orientation and position dependent receptive profiles. In particular, a specific framed sampling set and an associated Gabor system is determined by the Legendrian circle bundle structure of the 3manifold of contact elements on a surface (which models the V1−cortex), together with the presence of an almost complex structure on the tangent bundle of the surface (which models the retinal surface). Additionally, a maximal area of the signal planes, determined by the retinal surface, that provides a finite number of receptive profiles, sufficient for good encoding and decoding is identified. An extension of this model for receptive fields dependent on position, orientation, frequency and phase will be discussed.
Friday, October 13, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:30  10:30 am EDT"Something Cool I Know" Seminar10th Floor Classroom

11:00  11:30 am EDTComputing the Rank Invariant and the Matching Distance of MultiParameter Persistence Modules (with the help of discrete Morse theory)Post Doc/Graduate Student Seminar  11th Floor Lecture Hall
 Robyn Brooks, University of Utah
Abstract
Persistent Homology is a tool of Computation Topology which is used to determine the topological features of a space from a sample of data points. In this talk, I will introduce the (multi)persistence pipeline, as well as some basic tools from Discrete Morse Theory which can be used to better understand the multiparameter persistence module of a filtration. In particular, the addition of a discrete gradient vector field consistent with a multifiltration allows one to exploit the information contained in the critical cells of that vector field as a means of enhancing geometrical understanding of multiparameter persistence. I will present results from joint work with Claudia Landi, Asilata Bapat, Barbara Mahler, and Celia Hacker, in which we are able to show that the rank invariant for nD persistence modules can be computed by selecting a small number of values in the parameter space determined by the critical cells of the discrete gradient vector field. These values may be used to reconstruct the rank invariant for all other possible values in the parameter space. Time permitting, I will also introduce results from a subsequent work, in which we provide theoretical results for the computation of the matching distance in two dimensions.

11:30 am  12:00 pm EDTEphemeral Persistence Features and the Stability of Filtered Chain ComplexesPost Doc/Graduate Student Seminar  11th Floor Lecture Hall
 Ling Zhou, ICERM
Abstract
We strengthen the usual stability theorem for VietorisRips persistent homology of finite metric spaces by building upon constructions due to Usher and Zhang in the context of filtered chain complexes. The information present at the level of filtered chain complexes includes ephemeral points, i.e. points with zero persistence, which provide additional information to that present at homology level. The resulting invariant, called verbose barcode, which has a stronger discriminating power than the usual barcode, is proved to be stable under certain metrics which are sensitive to these ephemeral points. In the case of degree zero, we provide an explicit formula to compute this new metric between verbose barcodes.

1:30  3:00 pm EDTTopology+Neuro Working GroupGroup Work  10th Floor Classroom

3:00  3:30 pm EDTCoffee Break11th Floor Collaborative Space
Monday, October 16, 2023

8:50  9:00 am EDTWelcome11th Floor Lecture Hall
 Session Chair
 Caroline Klivans, Brown University

9:00  9:45 am EDTThe geometry of perceptual spaces of textures and objects11th Floor Lecture Hall
 Speaker
 Jonathan Victor, Weill Cornell Medical College
 Session Chair
 Carina Curto, The Pennsylvania State University
Abstract
Recent technological advances allow for massive populationlevel recordings of neural activity, raising the hope of achieving a detailed understanding of the linkage of neurophysiology and behavior. Achieving this linkage relies on the tenet that, viewed in the right way, the mapping between neural activity and behavior preserves similarities. At the behavioral level, these similarities are captured by the topology and geometry of perceptual spaces. With this motivation, I describe some recent studies of the geometry of several perceptual spaces, including “lowlevel” spaces of visual features, and “higherlevel” spaces dominated by semantic content. The experiments use a new, efficient psychophysical paradigm for collecting similarity judgments, and the analysis methods range from seeking Euclidean embeddings via nonmetric multidimensional scaling to strategies that make minimal assumptions about the underlying geometry. With these tools, we characterize how the geometry of the spaces vary with semantic content, and the aspects of these geometries that are taskdependent.

10:00  10:15 am EDTCoffee Break11th Floor Collaborative Space

10:15  11:00 am EDTTopology protects emergent dynamics and long timescales in biological networks11th Floor Lecture Hall
 Speaker
 Evelyn Tang, Rice University
 Session Chair
 Carina Curto, The Pennsylvania State University
Abstract
Long and stable timescales are often observed in complex biochemical networks, such as in emergent oscillations or memory. How these robust dynamics persist remains unclear, given the many stochastic reactions and shorter time scales of the underlying components. We propose a topological model with parsimonious parameters that produces long oscillations around the network boundary, effectively reducing the system dynamics to a lowerdimensional current. I will demonstrate how this can model the circadian clock of cyanobacteria, with efficient properties such as simultaneously increased precision and decreased cost. Our work presents a new mechanism for emergent dynamics that could be useful for various cognitive and biological functions.

11:15  11:45 am EDTOpen Problems SessionProblem Session  11th Floor Lecture Hall
 Session Chair
 Carina Curto, The Pennsylvania State University

11:45 am  1:30 pm EDTLunch/Free Time

1:30  2:15 pm EDTDiscovering the geometry of neural representations via topological tools.11th Floor Lecture Hall
 Speaker
 Vladimir Itskov, The Pennsylvania State University
 Session Chair
 Katie Morrison, University of Northern Colorado
Abstract
Neural representations of stimulus spaces often comes with a natural geometry. Perhaps the most salient examples of such neural populations are those with convex receptive fields (or tuning curves), such as place cells in hippocampus or neurons in V1. Geometry of neural representations is understood in a very limited number of wellstudied neural circuits. It is rather poorly understood in most other parts of the brain. This raises a natural question: can one infer such a geometry, based on the statistics of the neural responses alone? A crucial tool for inferring a geometry is a basis of coordinate functions that "respects" the underlying geometry, while providing meaningful lowdimensional approximations. Eigenfunctions of a Laplacian, derived from the underlying metric, serve as such basis in many scientific fields. However, spike trains, and other derived features of neural activity do not come with a natural metric, while they do come with an "intrinsic" probability distribution of neural activity patterns. Building on the tools from combinatorial topology, we introduce Hodge Laplacians associated with probability distributions on sequential data, such as spike trains. We demonstrate that these Laplacians have desirable properties with respect to the natural nullmodels, where the underlying neurons are independent. Our results establish a foundation for dimensionality reduction and Fourier analyses of probabilistic models, that are common in theoretical neuroscience and machinelearning.

2:30  2:40 pm EDTConnections between the topology of tasks, classifying spaces, and learned representationsLightning Talks  11th Floor Lecture Hall
 Speaker
 Thomas Burns, ICERM
 Session Chair
 Katie Morrison, University of Northern Colorado
Abstract
Modified state complexes (Burns & Tang, 2022) extend the mathematical framework of reconfigurable systems and state complexes due to Abrams, Ghrist & Peterson to study gridworlds  simple 2D environments inhabited of agents, objects, etc.. Such state complexes represent all possible configurations of a system as a single geometric space, thus making them conducive to study using geometric, topological, or combinatorial methods. Modified state complexes exhibit geometric defects (failure of Gromov's Link Condition) exactly where undesirable or dangerous states appear in the gridworld. We hypothesize that the modified state complex should be a classifying space for the n–strand braid group and that social place cell circuits in mammalian hippocampus use similar principles to represent and avoid danger.

2:40  2:50 pm EDTEmergence of highorder functional hubs in the human brainLightning Talks  11th Floor Lecture Hall
 Speaker
 Fernando Nobrega Santos, University of Amsterdam
 Session Chair
 Katie Morrison, University of Northern Colorado
Abstract
Network theory is often based on pairwise relationships between nodes, which is not necessarily realistic for modeling complex systems. Importantly, it does not accurately capture nonpairwise interactions in the human brain, often considered one of the most complex systems. In this work, we develop a multivariate signal processing pipeline to build highorder networks from time series and apply it to restingstate functional magnetic resonance imaging (fMRI) signals to characterize highorder communication between brain regions. We also propose connectivity and signal processing rules for building uniform hypergraphs and argue that each multivariate interdependence metric could define weights in a hypergraph. As a proof of concept, we investigate the most relevant threepoint interactions in the human brain by searching for highorder “hubs” in a cohort of 100 individuals from the Human Connectome Project. We find that, for each choice of multivariate interdependence, the highorder hubs are compatible with distinct systems in the brain. Additionally, the highorder functional brain networks exhibit simultaneous integration and segregation patterns qualitatively observable from their highorder hubs. Our work hereby introduces a promising heuristic route for hypergraph representation of brain activity and opens up exciting avenues for further research in highorder network neuroscience and complex systems.

2:50  3:00 pm EDTTopological feature selection for time series: an example with C. elegans neuronal dataLightning Talks  11th Floor Lecture Hall
 Speaker
 Johnathan Bush, University of Florida
 Session Chair
 Katie Morrison, University of Northern Colorado
Abstract
Neurons across the brain of the model organism C. elegans are known to share information by engaging in coordinated dynamic activity that evolves cyclically. Takens' theorem implies that a sliding window embedding of time series, such as neuronal activity, will preserve the topology of an orbit of the underlying dynamical system driving the time series. These orbits are then quantifiable by the persistent homology of the sliding window embedding. In this setting, we will describe a method for topological optimization in which each time series (e.g., a single neuron's activity) is assigned a score of its contribution to the global, coordinated dynamics of a collection of time series (e.g., the brain).

3:00  3:10 pm EDTThe Directed Merge Tree Distance and its ApplicationsLightning Talks  11th Floor Lecture Hall
 Speaker
 Xinyi Wang, Michigan State University
 Session Chair
 Katie Morrison, University of Northern Colorado
Abstract
Geometric graphs appear in many realworld datasets, such as embedded neurons, sensor networks, and molecules. We investigate the notion of distance between graphs and present a semimetric to measure the distance between two geometric graphs via the directional transform combined with the labeled merge tree distance. We introduce a way of rotating the sublevel set to obtain the merge trees, and represent the merge trees using a surjective multilabeling scheme. We then compute the distance between two representative matrices. Our distance is not only reflective of the information from the input graphs, but also can be computed in polynomial time. We illustrate its utility by implementation on a Passiflora leaf dataset.

3:10  3:20 pm EDTStructure Index: a graphbased method for point cloud data analysisLightning Talks  11th Floor Lecture Hall
 Speaker
 Julio Esparza Ibanez, Instituto Cajal  CSIC (Spanish National Research Council)
 Session Chair
 Katie Morrison, University of Northern Colorado
Abstract
A point cloud is a prevalent data format found in many fields of science, which involves the definition of points in an arbitrarily high dimensional space. Typically, each of these points is associated with additional values (i.e. features) which require interpretation in the representation space. For instance, in neuroscience, neural activity over time can be pictured as a point cloud in a highdimensional space. In these socalled neural manifolds, one may project different features onto the point cloud, such as any relevant behavioral variable. In this context, understanding if and how a given feature is structured along a point cloud can provide great insights into the neural representations. Here, I will introduce the Structure Index (SI), a graphbased metric developed to quantify how a given feature is structured along an arbitrarily highdimensional point cloud. The SI is defined from the overlapping distribution of data points sharing similar feature values in a given neighborhood of the cloud. Using arbitrary data clouds, I will show how the SI provides quantification of the degree of local versus global organization of feature distribution. Moreover, when applied to experimental studies of headdirection cells, the SI is able to retrieve consistent feature structure from both the high and lowdimensional representations. Overall, the SI provides versatile applications in the neuroscience and data science fields. We look to share the tool with other colleagues in the field, in order to promote communitybased testing and implementation.

3:20  3:30 pm EDTStructure in neural correlations during spontaneous activity: an experimental and topological approachLightning Talks  11th Floor Lecture Hall
 Speaker
 Nicole Sanderson, Penn State University
 Session Chair
 Katie Morrison, University of Northern Colorado
Abstract
Calcium imaging recordings of ~1000s of neurons in zebrafish larvae optic tectum in the absence of stimulation reveal spontaneous activity of neuronal assemblies that are both functionally coordinated and localized. To understand the functional structure of these assemblies, we study the pairwise correlations of the calcium signals of assembly neurons using techniques from topological data analysis (TDA). TDA can bring new insights when analyzing neural correlations, as many common techniques to do so, like spectral analyses, are sensitive to nonlinear monotonic transformations introduced in measurement. In contrast, a TDA construction called the order complex is invariant under monotonic transformations and can capture higher order structure in a set of pairwise correlations. We find that topological signatures derived from the order complex can identify distinct neural correlation structures during spontaneous activity. Our analyses further suggest a variety of possible assembly dynamics around the onset of spontaneous activation.

3:30  4:00 pm EDTCoffee Break11th Floor Collaborative Space

4:00  4:45 pm EDTTopology shapes dynamics of higherorder networks11th Floor Lecture Hall
 Speaker
 Ginestra Bianconi, Queen Mary University of London
 Session Chair
 Katie Morrison, University of Northern Colorado
Abstract
Higherorder networks capture the interactions among two or more nodes and they are raising increasing interest in the study of brain networks. Here we show that higherorder interactions are responsible for new nonlinear dynamical processes that cannot be observed in pairwise networks. We reveal how nonlinear topolody shapes dynamics, by defining Topological Kuramoto model and Topological global synchronization. These critical phenomena capture the synchronization of topological signals, i.e. dynamical signal defined not only on nodes but also on links, triangles and higherdimensional simplices in simplicial complexes. In this novel synchronized states for topological signals the dynamics localizes on the holes of the simplicial complexes. Moreover will discuss how the Dirac operator can be used to couple and process topological signals of different dimensions, formulating Dirac signal processing. Finally we will show how nonlinear dynamics can shape topology by formulating triadic percolation. In triadic percolation triadic interactions can turn percolation into a fullyfledged dynamical process in which nodes can turn on and off intermittently in a periodic fashion or even chaotically leading to period doubling and a route to chaos of the percolation order parameter. Triadic percolation changes drastically our understanding of percolation and can describe real systems in which the giant component varies significantly in time such as in brain functional networks and in climate.

5:00  6:30 pm EDTReception11th Floor Collaborative Space
Tuesday, October 17, 2023

9:00  9:45 am EDTA power law of cortical adaptation in neural populations11th Floor Lecture Hall
 Speaker
 Dario Ringach, University of California, Los Angeles
 Session Chair
 Matilde Marcolli, California Institute of Technology
Abstract
How do neural populations adapt to the timevarying statistics of sensory input? To investigate, we measured the activity of neurons in primary visual cortex adapted to different environments, each associated with a distinct probability distribution over a stimulus set. Within each environment, a stimulus sequence was generated by independently sampling form its distribution. We find that two properties of adaptation capture how the population responses to a given stimulus, viewed as vectors, are linked across environments. First, the ratio between the response magnitudes is a power law of the ratio between the stimulus probabilities. Second, the response directions are largely invariant. These rules can be used to predict how cortical populations adapt to novel, sensory environments. Finally, we show how the power law enables the cortex to signal unexpected stimuli preferentially and to adjust the metabolic cost of its sensory representation to the entropy of the environment.

10:00  10:15 am EDTCoffee Break11th Floor Collaborative Space

10:15  11:00 am EDTA geometric model of the visual and motor cortex11th Floor Lecture Hall
 Speaker
 Giovanna Citti, university of Bologna
 Session Chair
 Matilde Marcolli, California Institute of Technology
Abstract
I'll present a geometric model of the motor cortex, joint work with Alessandro Sarti. Each family of cells in the cortex is sensitive to a specific feature and will be described as a subRiemannian space. The propagation of the activity along cortical connectivity will be described as a subRiemannian differential equation. The stable states of the equation will describe the perceptual units, allowing to validate the model. It can be applied to selectivity of simple features (as for example direction of movement), or to more complex feautures, defined as perceptual units of the previous family of cells. The same instruments can describe both the visual and the motor cortex.

11:15  11:45 am EDTOpen Problems SessionProblem Session  11th Floor Lecture Hall
 Session Chair
 Matilde Marcolli, California Institute of Technology

11:50 am  12:00 pm EDTGroup Photo (Immediately After Talk)11th Floor Lecture Hall

12:00  1:30 pm EDTNetworking LunchWorking Lunch  11th Floor Lecture Hall

1:30  2:15 pm EDTTopological analysis of sensoryevoked network activity11th Floor Lecture Hall
 Speaker
 Alex Reyes, New York University
 Session Chair
 Peter Thomas, Case Western Reserve University
Abstract
Sensory stimuli evoke activity in a population of neurons in cortex. In topographically organized networks, activated neurons with similar receptive fields occur within a relatively confined area, suggesting that the spatial distribution and firing dynamics of the neuron population contribute to processing of sensory information. However, inherent variability in neuronal firing, makes it difficult to determine which neurons encode signal and which represent noise. Here, we use simplicial complexes to identify functionally relevant neurons whose activities are likely to be propagated and to distinguish between multiple populations activated during complex stimuli. Moreover, preliminary analyses suggest that changes in the extent and magnitude of network activity can be described abstractly as the movement of points on the surface of a torus.

2:30  2:40 pm EDTAnalyzing spatiotemporal patterns using geometric scattering and persistent homologyLightning Talks  11th Floor Lecture Hall
 Speaker
 Dhananjay Bhaskar, Yale University
 Session Chair
 Peter Thomas, Case Western Reserve University
Abstract
I will introduce Geometric Scattering Trajectory Homology (GSTH), a general framework for analyzing complex spatiotemporal patterns that emerge from coordinated signaling and communication in a variety of biological contexts, including Ca2+ activity in the prefrontal visual cortex in response to grating stimuli, and entrainment of theta oscillations in the brain during memory encoding and retrieval tasks. We tested this framework by recovering model parameters, drug treatments and stimuli from simulation and experimental data. Additionally, we show that learned representations in GSTH capture the degree of synchrony, phase transitions, and quasiperiodicity of the underlying signaling pattern at multiple scales, showing promise towards uncovering intricate neural communication mechanisms.

2:40  2:50 pm EDTMultiple Neural Spike Train Data Analysis Using Persistent HomologyLightning Talks  11th Floor Lecture Hall
 Speaker
 Huseyin Ayhan, Florida State University
 Session Chair
 Peter Thomas, Case Western Reserve University
Abstract
A neuronal spike train is the recorded sequence of times when a neuron fires action potentials, also known as spikes. Studying the collective activities of neurons as a network of spike trains can help us gain an understanding of how they function. These networks are wellsuited for the application of topological tools. In this lightning talk, I will briefly explain how persistent homology, one of the most powerful tools of TDA, can be applied to understand and compare the topology of these networks.

2:50  3:00 pm EDTVariability of topological features on brain functional networks in precision restingstate fMRI.Lightning Talks  11th Floor Lecture Hall
 Speaker
 Juan Carlos DíazPatiño, Universidad Nacional Autónoma de México
 Session Chair
 Peter Thomas, Case Western Reserve University
Abstract
Nowadays, much scientific literature discusses Topological Data Analysis (TDA) applications in Neuroscience. Nevertheless, a fundamental question in the field is, how different are fMRI in one individual over a short time? Are they similar? What are the changes between individuals? This talk presents the approach used to study restingstate functional Magnetic Resonance Images (fMRI) with TDA methods using the VietorisRips filtration over a weighted network and looking for statistical differences between their Betti Curves and also a vectorization method using the Minimum Spanning Tree.

3:00  3:10 pm EDTGabor Frames and Contact structures: Signal encoding and decoding in the primary visual cortexLightning Talks  11th Floor Lecture Hall
 Speaker
 Vasiliki Liontou, ICERM
 Session Chair
 Peter Thomas, Case Western Reserve University
Abstract
Contact structures and Gabor functions have been used, independently, to model the activity of the mammalian primary visual cortex. Gabor functions are also used in signal analysis and in particular in signal encoding and decoding. In particular, a onedimensional signal, an $L^2$ function of one variable , can be represented in two dimensions, with time and frequency as coordinates. The signal is expanded into a series of Gabor functions (an analog of a Fourier basis), which are constructed from a single seed function by applying time and frequency translations. This talk summarizes the construction of a framework of signal analysis on models of $V_1$, determined by its contact structure and suggests a mathematical model of $V_1$ which allows the encoding and decoding of a signal by a discrete family of orientation and position dependent receptive profiles.

3:10  3:20 pm EDTHarmonic Analysis of SequencesLightning Talks  11th Floor Lecture Hall
 Speaker
 Hannah Santa Cruz, Penn State
 Session Chair
 Peter Thomas, Case Western Reserve University
Abstract
The Combinatorial Laplacian is a popular tool in Graph and Network analysis. Recent work has proposed the use of Hodge Laplacians and the Magnetic Laplacian to analyze Simplicial Complexes and Directed Graphs respectively. We continue this work, by interpreting the Hodge Laplacian associated to a weighed simplicial complex, in terms of a weight function which is induced by a probability distribution. In particular, we develop a null hypothesis weighed simplicial complex model, induced by an independent distribution on the vertices, and show that the associated Laplacian is trivial. We extend this work to Sequence Complexes, where we consider the faces to be sequences, allowing for repeated vertices and distinguishing sequences with different orderings. In this setting, we also explore the Laplacian associated to a weight function induced by an independent distribution on the vertices, and completely describe it’s eigen spectrum, which is no longer trivial but still simple. Our analysis and findings contribute to the broader field of spectral graph theory and provide a deeper understanding of Laplacians on simplicial and sequence complexes, paving the way for further exploration and applications of Laplacian operators.

3:20  3:30 pm EDTGroup symmetry: a designing principle of recurrent neural circuits in the brainLightning Talks  11th Floor Lecture Hall
 Speaker
 Wenhao Zhang, UT Southwestern Medical Center
 Session Chair
 Peter Thomas, Case Western Reserve University
Abstract
Equivariant representation is necessary for the brain and artificial perceptual systems to faithfully represent the stimulus under some (Lie) group transformations. However, it remains unknown how recurrent neural circuits in the brain represent the stimulus equivariantly, nor the neural representation of abstract group operators. In this talk, I will present my recent attempts to narrow down this gap. We recently used the onedimensional translation group and the temporal scaling group as examples to explore the general recurrent neural circuit mechanism of the equivariant stimulus representation. We found that a continuous attractor network (CAN), a canonical neural circuit model, selfconsistently generates a continuous family of stationary population responses (attractors) that represents the stimulus equivariantly. We rigorously derived the representation of group operators in the circuit dynamics. The derived circuits are comparable with concrete neural circuits discovered in the brain and can reproduce neuronal responses that are consistent with experimental data. Our model for the first time analytically demonstrates how recurrent neural circuitry in the brain achieves equivariant stimulus representation.

3:30  4:00 pm EDTCoffee Break11th Floor Collaborative Space

4:00  4:45 pm EDTA Neuron as a Direct DataDriven Controller11th Floor Lecture Hall
 Speaker
 Dmitri Chklovskii, Flatiron Institute & NYU Neuroscience Institute
 Session Chair
 Peter Thomas, Case Western Reserve University
Abstract
"Efficient coding theories have elucidated the properties of neurons engaged in early sensory processing. However, their applicability to downstream brain areas, whose activity is strongly correlated with behavior, remains limited. Here we present an alternative viewpoint, casting neurons as feedback controllers in closed loops comprising fellow neurons and the external environment. Leveraging the novel Direct DataDriven Control (DDDC) framework, we model neurons as biologically plausible controllers which implicitly identify loop dynamics, infer latent states and optimize control. Our DDDC neuron model accounts for multiple neurophysiological observations, including the transition from potentiation to depression in SpikeTimingDependent Plasticity (STDP) with its asymmetry, the temporal extent of feedforward and feedback neuronal filters and their adaptation to input statistics, imprecision of the neuronal spikegeneration mechanism under constant input, and the prevalence of operational variability and noise in the brain. The DDDC neuron contrasts with the conventional, feedforward, instantaneously responding McCullochPittsRosenblatt unit, thus offering an alternative foundational building block for the construction of biologicallyinspired neural networks.
Wednesday, October 18, 2023

9:00  9:45 am EDTObject representation in the brain11th Floor Lecture Hall
 Speaker
 Dmitry Rinberg, New York University
 Session Chair
 Tatyana Sharpee, Salk Institute
Abstract
Animals can recognize sensory objects that are relevant to their behavior, such as familiar sounds, faces, or the smell of specific fruits. This ability relies on the sensory system performing two key computational tasks: first, distinguishing a particular object from all other objects, and second, generalizing across some range of stimuli. The latter implies that objects have some range of variability in the stimulus space  a smell of an apple may be attributed to multiple different apple varieties with similar chemical composition. Additionally, as the presented stimuli become more different from what's expected or familiar, the ability to correctly identify them decreases. Such computational requirements set up constrains for the geometry of the neural space of object representation in the brain. In this presentation, I will delve into our efforts to investigate object representation in the brain, employing optogenetic pattern stimulation of the peripheral olfactory system to create highly controllable synthetic odor stimuli. We have developed a behavioral paradigm that enables us to address both essential computational prerequisites: discriminating between and generalizing across stimuli. Furthermore, we have quantified both behavioral responses and neural activity. Our findings have revealed that the neural space governing stimulus responses conforms closely to the criteria for effective object representation, closely mirroring behavioral outcomes.

10:00  10:15 am EDTCoffee Break11th Floor Collaborative Space

10:15  11:00 am EDTThe developmental timeline of the grid cell torus and how we are studying it11th Floor Lecture Hall
 Speaker
 Benjamin Dunn, Norwegian University of Science and Technology
 Session Chair
 Tatyana Sharpee, Salk Institute

11:15  11:45 am EDTOpen Problems SessionsProblem Session  11th Floor Lecture Hall
 Session Chair
 Tatyana Sharpee, Salk Institute

12:00  1:30 pm EDTLunch/Free Time

1:45  2:30 pm EDTInformational and topological signatures of individuality and age11th Floor Lecture Hall
 Speaker
 Giovanni Petri, CENTAI Institute
 Session Chair
 Tatyana Sharpee, Salk Institute
Abstract
Network neuroscience is a dominant paradigm for understanding brain function.Functional Connectivity (FC) encodes neuroimaging signals in terms of the pairwise correlation patterns of coactivations between brain regions. However, FC is by construction limited to such pairwise relations. In this seminar, we explore functional activations as a topological space via tools from topological data analysis. In particular, we analyze the resting fMRI data of populations of healthy subjects across ages, and demonstrate that algebraictopological features extracted from brain activity are effective for brain fingerprinting. By computing persistent homology and constructing topological scaffolds, we show that these features outperform FC in discriminating between individuals and ages. That is, the topological structures are more similar for the same individual across different recording sessions than across individuals. Similarly, we find that topological observables improve discrimination of individuals of different ages. Finally, we show that the regions highlighted by our topological methods are characterized by characteristic patterns of information redundancy and synergy which are not share by regions that are topologically unimportant, hence establishing a first direct link between topology and information theory in neuroscience.

2:45  2:55 pm EDTEphemeral Persistence Features and the Stability of Filtered Chain ComplexesLightning Talks  11th Floor Lecture Hall
 Speaker
 Ling Zhou, ICERM
 Session Chair
 Tatyana Sharpee, Salk Institute
Abstract
We strengthen the usual stability theorem for VietorisRips persistent homology of finite metric spaces by building upon constructions due to Usher and Zhang in the context of filtered chain complexes. The information present at the level of filtered chain complexes includes ephemeral points, i.e. points with zero persistence, which provide additional information to that present at homology level. The resulting invariant, called verbose barcode, which has a stronger discriminating power than the usual barcode, is proved to be stable under certain metrics which are sensitive to these ephemeral points. In the case of degree zero, we provide an explicit formula to compute this new metric between verbose barcodes.

2:55  3:05 pm EDTHomotopy and singular homology groups of finite graphsLightning Talks  11th Floor Lecture Hall
 Speaker
 Nikola Milicevic, Pennsylvania State University
 Session Chair
 Tatyana Sharpee, Salk Institute
Abstract
We verify analogues of classical results for higher homotopy groups and singular homology groups of (Cech) closure spaces. Closure spaces are a generalization of topological spaces that also include graphs and directed graphs and are thus a bridge that connects classical algebraic topology with the more applied side of topology, such as digital topology. More specifically, we show the existence of a long exact sequence for homotopy groups of pairs of closure spaces and that a weak homotopy equivalence induces isomorphisms for homology groups. Our main result is the construction of a weak homotopy equivalences between the geometric realizations of (directed) clique complexes and their underlying (directed) graphs. This implies that singular homology groups of finite graphs can be efficiently calculated from finite combinatorial structures, despite their associated chain groups being infinite dimensional. This work is similar to the work McCord did for finite topological spaces, but in the context of closure spaces. Our results also give a novel approach for studying (higher) homotopy groups of discrete mathematical structures such as digital images.

3:05  3:15 pm EDTHebbian learning of cyclic structures of neural codeLightning Talks  11th Floor Lecture Hall
 Speaker
 Nikolas Schonsheck, University of Delaware
 Session Chair
 Tatyana Sharpee, Salk Institute
Abstract
Cyclic structures are a class of mesoscale features ubiquitous in both experimental stimuli and the activity of neural populations encoding them. Important examples include encoding of head direction, grid cells in spatial navigation, and orientation tuning in visual cortex. The central question of this short talk is: how does the brain faithfully transmit cyclic structures between regions? Is this a generic feature of neural circuits, or must this be learned? If so, how? While cyclic structures are difficult to detect and analyze with classical methods, tools from algebraic topology have proven to be particularly effective in understanding cyclic structures. Recently, work of Yoon et al. develops a topological framework to match cyclic coding patterns in distinct populations that encode the same information. We leverage this framework to show that, beginning with a random initialization, Hebbian learning robustly supports the propagation of cyclic structures through feedforward networks. This is joint work with Chad Giusti.

3:15  3:25 pm EDTThe bifiltration of a relation and unsupervised inference of neural representationsLightning Talks  11th Floor Lecture Hall
 Speaker
 Melvin Vaupel, Norwegian Institute of Science and Technology
 Session Chair
 Tatyana Sharpee, Salk Institute
Abstract
To neural activity one may associate a space of correlations and a space of population vectors. These can provide complementary information. Assume the goal is to infer properties of a covariate space, represented by the recorded neurons. Then the correlation space is better suited if multiple neural modules are present, while the population vector space is preferable if neurons have nonconvex receptive fields. In this talk I will explain how to coherently combine both pieces of information in a bifiltration using Dowker complexes and their total weight filtrations.

3:30  4:00 pm EDTCoffee Break11th Floor Collaborative Space

4:00  4:45 pm EDTAn application of neighbourhoods in directed graphs in the classification of binary dynamics11th Floor Lecture Hall
 Speaker
 Ran Levi, University of Aberdeen
 Session Chair
 Tatyana Sharpee, Salk Institute
Abstract
A binary state on a graph means an assignment of binary values to its vertices. For example, if one encodes a network of spiking neurons as a directed graph, then the spikes produced by the neurons at an instant of time is a binary state on the encoding graph. Allowing time to vary and recording the spiking patterns of the neurons in the network produces an example of a binary dynamics on the encoding graph, namely a oneparameter family of binary states on it. The central object of study in this talk is the neighbourhood of a vertex v in a graph G, namely the subgraph of G that is generated by v and all its direct neighbours in G. We present a topological/graph theoretic method for extracting information out of binary dynamics on a graph, based on a selection of a relatively small number of vertices and their neighbourhoods. As a test case we demonstrate an application of the method to binary dynamics that arises from sample activity on the Blue Brain Project reconstruction of cortical tissue of a rat.
Thursday, October 19, 2023

9:00  9:45 am EDTHow to simulate a connectome?11th Floor Lecture Hall
 Speaker
 Srinivas Turaga, HHMI  Janelia Research Campus
 Session Chair
 Carina Curto, The Pennsylvania State University
Abstract
We can now measure the connectivity of every neuron in a neural circuit, but we are still blind to other biological details, including the dynamical characteristics of each neuron. The degree to which connectivity measurements alone can inform understanding of neural computation is an open question. We show that with only measurements of the connectivity of a biological neural network, we can predict the neural activity underlying neural computation. Our mechanistic model makes detailed experimentally testable predictions for each neuron in the connectome. We found that model predictions agreed with experimental measurements of neural activity across 24 studies. Our work demonstrates a strategy for generating detailed hypotheses about the mechanisms of neural circuit function from connectivity measurements. https://www.biorxiv.org/content/10.1101/2023.03.11.532232

10:00  10:15 am EDTCoffee Break11th Floor Collaborative Space

10:15  11:00 am EDTFrom single neurons to complex networks using algebraic topology11th Floor Lecture Hall
 Speaker
 Lida Kanari, EPFL/Blue Brain
 Session Chair
 Carina Curto, The Pennsylvania State University
Abstract
Topological Data Analysis has been successfully used in a variety of applications including protein study, cancer detection, and study of porous materials. Based on algebraic topology, we created a robust topological descriptor of neuronal morphologies and used it to classify and cluster neurons and microglia. But what can topology tell us about the functional roles of neurons in the brain? In this talk, I will focus on focus on the study of the human brain, delving deeper into the fundamental question of neuroscience “whether dendritic structures hold the key to enhanced cognitive abilities”. Starting from the topological differences of mouse and human neurons, we create artificial networks for both species. We show that topological complexity leads to highly interconnected pyramidaltopyramidal and higherorder networks, which is unexpected in view of reduced neuronal density in humans compared to the mouse neocortex. We thus present robust evidence that increased topological complexity in human neurons ultimately leads to highly interconnected cortical networks despite reduced neuronal density. https://www.biorxiv.org/content/10.1101/2023.09.11.557170v1

11:30 am  1:30 pm EDTOpen Problems LunchWorking Lunch

1:30  2:15 pm EDTRapid emergence of latent knowledge in the sensory cortex drives learning11th Floor Lecture Hall
 Speaker
 Kishore Kuchibhotla, Johns Hopkins University
 Session Chair
 Horacio Rotstein, New Jersey Institute of Technology
Abstract
Largescale neural recordings provide an opportunity to better understand how the brain implements critical behavioral computations related to goaldirected learning. Here, I will argue that revisiting our understanding of the shape of the learning curve and its underlying cognitive drivers is essential for uncovering its neural basis. Rather than thinking about learning as either ‘slow’ or ‘sudden’, I will argue that learning is better interpreted as a combination of the two. I will provide behavioral evidence that goaldirected learning can be dissociated into two parallel processes: knowledge acquisition which is rapid with steplike improvements and behavioral expression, which is slower and more variable, with animals exhibiting rudimentary forms of hypothesis testing. This behavioral approach has allowed us to isolate the associative (knowledgerelated) and nonassociative (performancerelated) components that influence learning. I will present probabilistic optogenetic and longitudinal twophoton imaging results that neural dynamics in the auditory cortex are crucial for auditory guided, goaldirected learning. Conjoint representations of sensory and nonsensory variables in the same auditory cortical network evolve in a structured and dynamic manner, actively integrating multimodal signals via dissociable neural ensembles. Our data suggest that the sensory cortex is an associative engine with the cortical network shifting from being largely stimulusdriven to one that is optimized for behavioral needs.

2:30  3:15 pm EDTMargin learning in spiking neurons11th Floor Lecture Hall
 Speaker
 Robert Gütig, Charité Medical School Berlin
 Session Chair
 Horacio Rotstein, New Jersey Institute of Technology
Abstract
Learning novel sensory features from few examples is a remarkable ability of humans and other animals. For example, we can recognize unfamiliar faces or words after seeing or hearing them only a few times, even in different contexts and noise levels. Previous work has shown that spiking neural networks can learn to detect unknown features in unsegmented input streams using multispike tempotron learning. However, this method requires many training patterns and the learned solutions can be sensitive to noise. In this work, we use multispike tempotron learning to implement margin learning in spiking neurons. Specifically, we introduce regularization terms that enable leakyintegrateandfire neurons to learn to detect recurring features using orders of magnitude less training data and converge to robust solutions. We test the novel learning rule on unsegmented spoken digit sequences contained in the TIDIGITS speech data set and find a twofold improvement in detection probability over the original learning algorithm. Our work shows how neurons can learn to detect embedded features from a limited number of unsegmented samples, provides fundamental bounds for the noise robustness of the leaky integrateandfire model and ties mathematically principled gradientbased optimization to biologically plausible learning in spiking neurons.

3:30  4:00 pm EDTCoffee Break11th Floor Collaborative Space

4:00  4:45 pm EDTMetastable dynamics in cortical circuits11th Floor Lecture Hall
 Speaker
 Giancarlo La Camera, Stony Brook University
 Session Chair
 Horacio Rotstein, New Jersey Institute of Technology
Abstract
I will discuss recent results on metastable dynamics in cortical circuits, characterized by seemingly random switching among a finite number of discrete states. Single states and their metastable dynamics can reflect abstract features of external stimuli as well as internal deliberations, and have been proposed as supporting a role in a variety of functions including sensory coding, expectation, decision making and behavioral accuracy. Many results in this context have been captured by spiking network models with a clustered architecture. I will review data and models while trying to provide a modelinspired unitary view of the phenomena discussed. If time permits, I will present a model of how this type of dynamics can emerge from (and coexist with) experiencedependent plasticity in a network of spiking neurons.
Friday, October 20, 2023

9:00  9:45 am EDTLearning topological structure in neural population codes11th Floor Lecture Hall
 Speaker
 Chad Giusti, Oregon State University
 Session Chair
 Vladimir Itskov, The Pennsylvania State University
Abstract
The stimulus space model for neural population activity describes the activity of individual neurons as points localized in a metric stimulus space, with firing rate falling off with distance to individual stimuli. We will briefly review this model, and discuss how methods from topological data analysis allow us to extract qualitative structure and coordinate systems for such spaces from measures of neural population activity. We will briefly explore challenges that arise when studying whether and how multiple neural populations encode the same topological structure, and discuss recent experiments involving Hebbian learning for circular coordinate systems in feedforward networks. No prior knowledge of topological methods will be assumed.

10:00  10:45 am EDTTopological tracing of encoded circular coordinates between neural populations11th Floor Lecture Hall
 Speaker
 Iris Yoon, Wesleyan University
 Session Chair
 Vladimir Itskov, The Pennsylvania State University
Abstract
Recent developments in in vivo neuroimaging in animal models have made possible the study of information coding in large populations of neurons and even how that coding evolves in different neural systems. Topological methods, in particular, are effective at detecting periodic, quasiperiodic, or circular features in neural systems. Once we detect the presence of circular structures, we face the problem of assigning semantics: what do the circular structures in a neural population encode? Are they reflections of an underlying physiological activity, or are they driven by an external stimulus? If so, which specific features of the stimulus are encoded by the neurons? To address this problem, we introduced the method of analogous bars (Yoon, Ghrist, Giusti 2023). Given two related systems, say a stimulus system and a neural population, or two related neural populations, we utilize the dissimilarity between the two systems and Dowker complexes to find shared features between the two systems. We then leverage this information to identify related features between the two systems. In this talk, I will briefly explain the mathematics underlying the analogous bars method. I will then present applications of the method in studying neural population coding and propagation on simulated and experimental datasets. This work is joint work with Gregory HenselmanPetrusek, Lori Ziegelmeier, Robert Ghrist, Spencer Smith, Yiyi Yu, and Chad Giusti.

11:00  11:30 am EDTCoffee Break11th Floor Collaborative Space

11:30 am  12:15 pm EDTThe neurogeometry of the visual cortex11th Floor Lecture Hall
 Speaker
 Alessandro Sarti, National Center of Scientific Research, EHESS, Paris
 Session Chair
 Vladimir Itskov, The Pennsylvania State University
Abstract
I will consider a model of the primary visual cortex in terms of Lie groups equipped with a subRiemannian metric. The shape of receptive profiles as well as the patterns of short range and long range connectivity will have a precise geometric meaning. After showing examples of contour completion in the subRiemannian structure, I will consider the coupling of heterogeneous cells to model amodal completion (Kanitza triangle) as well as contrastcostancy image reconstruction in V1. The reconstruction involves a new type of Poisson problem with heterogeneous differential operators. (Joint work with Giovanna Citti)

12:30  2:00 pm EDTLunch/Free Time

2:00  2:45 pm EDTFinal Open Problems SessionProblem Session  11th Floor Lecture Hall
 Session Chair
 Carina Curto, The Pennsylvania State University

3:30  4:00 pm EDTCoffee Break11th Floor Collaborative Space
Monday, October 23, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

10:00  11:00 am EDTOpen ProblemsJournal Club  10th Floor Classroom

3:00  3:30 pm EDTCoffee Break10th Floor Collaborative Space

3:30  5:00 pm EDTA modern tour of Hopfield networks: from ferromagnetism to ChatGPT  Tom BurnsGroup Work  10th Floor Classroom
Tuesday, October 24, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

3:00  3:30 pm EDTCoffee Break10th Floor Collaborative Space
Wednesday, October 25, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00  10:00 am EDTProfessional Development: Job ApplicationsProfessional Development  11th Floor Lecture Hall

12:00  1:30 pm EDTTDA TutorialTutorial  10th Floor Classroom

3:00  3:30 pm EDTCoffee Break10th Floor Collaborative Space

3:30  4:30 pm EDTBump attractors and waves in networks of leaky integrateandfire neurons11th Floor Lecture Hall
 Speaker
 Daniele Avitabile, Vrije Universiteit Amsterdam
 Session Chair
 Peter Thomas, Case Western Reserve University
Thursday, October 26, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00  10:30 am EDTTDA TutorialTutorial  10th Floor Classroom

3:00  3:30 pm EDTCoffee Break10th Floor Collaborative Space
Friday, October 27, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:30  10:30 am EDT"Something Cool I Know" Seminar10th Floor Classroom

11:00  11:30 am EDTOn the Relation Between Infinitesimal Shape Response Curves and PhaseAmplitude Reduction for Single and Coupled LimitCycle OscillatorsPost Doc/Graduate Student Seminar  10th Floor Classroom
 Maxwell Kreider, Case Western Reserve University
Abstract
Phase reduction is a wellestablished method to study weakly driven and weakly perturbed oscillators. Traditional phasereduction approaches characterize the perturbed system dynamics solely in terms of the timing of the oscillations. In the case of large perturbations, the introduction of amplitude (isostable) coordinates improves the accuracy of the phase description by providing a sense of distance from the underlying limit cycle. Importantly, phaseamplitude coordinates allow for the study of both the timing and shape of system oscillations. A parallel tool is the infinitesimal shape response curve (iSRC), a variational method that characterizes the shape change of a limitcycle oscillator under sustained perturbation. Despite the importance of oscillation amplitude in a wide range of physical systems, systematic studies on the shape change of oscillations remain scarce. Both phaseamplitude coordinates and the iSRC represent methods to analyze oscillation shape change, yet a relationship between the two has not been previously explored. In this work, we establish the iSRC and phaseamplitude coordinates as complementary tools to study oscillation amplitude. We extend existing iSRC theory and specify conditions under which a general class of systems can be analyzed by the joint iSRC phaseamplitude approach. We show that the iSRC takes on a dramatically simple form in phaseamplitude coordinates, and directly relate the phase and isostable response curves to the iSRC. We apply our theory to weakly perturbed single oscillators, and to study the synchronization and entrainment of coupled oscillators.

11:30 am  12:00 pm EDTStructure in neural correlations during spontaneous activity: an experimental and topological approachPost Doc/Graduate Student Seminar  10th Floor Classroom
 Nicole Sanderson, Penn State University
Abstract
Calcium imaging recordings of ~1000s of neurons in zebrafish larvae optic tectum in the absence of stimulation reveal spontaneous activity of neuronal assemblies that are both functionally coordinated and localized. To understand the functional structure of these assemblies, we study the pairwise correlations of the calcium signals of assembly neurons using techniques from topological data analysis (TDA). TDA can bring new insights when analyzing neural correlations, as many common techniques to do so, like spectral analyses, are sensitive to nonlinear monotonic transformations introduced in measurement. In contrast, a TDA construction called the order complex is invariant under monotonic transformations and can capture higher order structure in a set of pairwise correlations. We find that topological signatures derived from the order complex can identify distinct neural correlation structures during spontaneous activity. Our analyses further suggest a variety of possible assembly dynamics around the onset of spontaneous activation.

1:30  3:00 pm EDTTopology+Neuro Working GroupGroup Work  10th Floor Classroom

3:00  3:30 pm EDTCoffee Break10th Floor Collaborative Space
Monday, October 30, 2023

8:50  9:00 am EDTWelcome11th Floor Lecture Hall
 Session Chair
 Brendan Hassett, ICERM/Brown University

9:00  9:45 am EDTHow to perform computations in lowrank excitatoryinhibitory spiking networks: a geometric view11th Floor Lecture Hall
 Speaker
 Christian Machens, Champalimaud Foundation
 Session Chair
 Katie Morrison, University of Northern Colorado
Abstract
Models of neural networks can be largely divided into two camps. On one end, mechanistic models such as balanced spiking networks resemble activity regimes observed in data, but are often limited to simple computations. On the other end, functional models like trained deep networks can perform a multitude of computations, but are far removed from experimental physiology. Here, I will introduce a new framework for excitatoryinhibitory spiking networks which retains key properties of both mechanistic and functional models. The principal insight is to cast the problem of spiking dynamics in the lowdimensional space of population modes rather than in the original neural space. Neural thresholds then become convex boundaries in the population space, and population dynamics is either attracted (I population) or repelled (E population) by these boundaries. The combination of E and I populations results in balanced, inhibitionstabilized networks which are capable of universal function approximation. I will illustrate these insights with simple, geometric toy models, and I will argue that need to reconsider the very basics of how we think about neural networks.

10:00  10:15 am EDTCoffee Break11th Floor Collaborative Space

10:15  11:00 am EDTStructured variability and its roles in neural computation: the hippocampus perspective11th Floor Lecture Hall
 Speaker
 Cristina Savin, NYU
 Session Chair
 Katie Morrison, University of Northern Colorado
Abstract
Local circuit interactions play a key role in neural computation and are dynamically shaped by experience. However, measuring and assessing their effects during behavior remains a challenge. Here we combine techniques from statistical physics and machine learning to develop new tools for determining the effects of local network interactions on neural population activity. This approach reveals highly structured local interactions between hippocampal neurons, which make the neural code more precise and easier to read out by downstream circuits, across different levels of experience. More generally, the novel combination of theory and data analysis in the framework of maximum entropy models enables traditional neural coding questions to be asked in a naturalistic setting.

11:15  11:45 am EDTOpen problems DiscussionProblem Session  11th Floor Lecture Hall
 Session Chairs
 Carina Curto, The Pennsylvania State University
 Katie Morrison, University of Northern Colorado

11:45 am  1:30 pm EDTLunch/Free Time

1:30  2:15 pm EDTThe topology, geometry, and combinatorics of feedforward neural networks11th Floor Lecture Hall
 Speaker
 Julia E Grigsby, Boston College
 Session Chair
 Nora Youngs, Colby College
Abstract
Deep neural networks are a class of parameterized functions that have proven remarkably successful at making predictions about unseen data from finite labeled data sets. They do so even in settings when classical intuition suggests that they ought to be overfitting (aka memorizing) the data. I will begin by describing the structure of neural networks and how they learn. I will then advertise one of the theoretical questions animating the field: how does the relationship between the number of parameters and the size of the data set impact the dynamics of how they learn? Along the way I will emphasize the many ways in which topology, geometry, and combinatorics play a role in the field.

2:30  2:40 pm EDTCorrelated dense associative memoriesLightning Talks  11th Floor Lecture Hall
 Speaker
 Thomas Burns, ICERM
 Session Chair
 Nora Youngs, Colby College
Abstract
Associative memory networks encode memory patterns by establishing dynamic attractors centred on specific states of neurons. These attractors, nonetheless, are not constrained to remain fixed points or singular memory patterns. Through the correlation of these attractors and asymmetry of the network's connections, we can depict sequences or sets of stimuli that are temporally or spatially connected via mathematical graphs. By further modulating these correlations using inhibitory (antiHebbian) learning rules, we show how structures may be hierarchicallysegmented at multiple scales. Such structures can also be used to conduct 'computations' where sequences of (quasi)attractors code for an 'associationist' algorithmic syntax. This therefore illustrates how auto and heteroassociative recall processes can form as a basis for executing more complex network behaviours, which is aided by the highly nonlinear energy landscape inherent in dense associative memory networks (also known as modern Hopfield networks).

2:40  2:50 pm EDTUsing spherical coordinates and Stiefel manifolds to decode neural dataLightning Talks  11th Floor Collaborative Space
 Speaker
 Nikolas Schonsheck, University of Delaware
 Session Chair
 Nora Youngs, Colby College
Abstract
A central challenge in modern computational neuroscience is decoding behaviors and stimuli from the activity of the neural populations that encode them. In this talk, I will describe a few examples of how one can do this using novel techniques from algebraic topology. I will describe a method that is wellsuited to stimuli with spherical geometry, and another method that can be used on Stiefel manifolds. For the latter, I will discuss an application to simulated data on a partially sampled circular stimulus space where standard persistence techniques fail.

2:50  3:00 pm EDTActive sensing and switching in neural population activityLightning Talks  11th Floor Collaborative Space
 Speaker
 Soon Ho Kim, Georgia Institute of Technology
 Session Chair
 Nora Youngs, Colby College
Abstract
While sensory processing and motor control are often studied in isolation, perception and action are fundamentally intertwined. Here we study electrophysiological recordings of the barrel cortex of mice during a shape discrimination task in which mice actively whisk their surroundings to identify and discriminate objects. We find significant changes in the intra and interlaminar functional connectivity during whisking trials when compared to resting state, with information flow from superficial to deep layers more significant. We further use a novel generalized linear model developed for spiking neural activity coupled with a hiddenMarkov model to analyze state transitions in neural activity as well as in behavior. The results shed light into the neural activity underpinning active whisking and sensory perception.

3:00  3:10 pm EDTOn the Convexity of Certain 4Maximal Neural CodesLightning Talks  11th Floor Collaborative Space
 Speaker
 Natasha Crepeau, University of Washington
 Session Chair
 Nora Youngs, Colby College
Abstract
A convex neural code describes the regions of an arrangement of convex open sets in Euclidean space, where each set corresponds to the place field of a neuron in an animal's environment. The convexity of neural codes with up to three maximal codewords is completely characterized by the lack of local obstructions, introduced by Giusti and Itskov. Another indicator of nonconvexity introduced by Perez, Matusevich, and Shiu are wheels. It is conjectured by Jeffs that a 4maximal neural code is convex if and only if it has no local obstructions and no wheels. By studying the nerve of the maximal codewords of a given code, we resolve this conjecture for certain classes of 4maximal neural codes. Additionally, we describe a type of wheel always contained in a family of 4maximal neural codes, with a goal of identifying more.

3:30  4:00 pm EDTCoffee Break11th Floor Collaborative Space

4:00  4:45 pm EDTTBD11th Floor Lecture Hall
 Speaker
 Leenoy Meshulam, University of Washington
 Session Chair
 Nora Youngs, Colby College

5:00  6:30 pm EDTReception11th Floor Collaborative Space
Tuesday, October 31, 2023

9:00  9:45 am EDTHyperbolic geometry and power law adaptation in neural circuits11th Floor Lecture Hall
 Speaker
 Tatyana Sharpee, Salk Institute
 Session Chair
 Zachary Kilpatrick, University of Colorado Boulder

10:00  10:15 am EDTCoffee Break11th Floor Collaborative Space

10:15  11:00 am EDTWhere can a place cell put its fields? Let us count the ways11th Floor Lecture Hall
 Speaker
 Thibaud Taillefumier, UT Austin
 Session Chair
 Zachary Kilpatrick, University of Colorado Boulder
Abstract
A hippocampal place cell exhibits multiple firing fields within and across environments. What factors determine the configuration of these fields, and could they be set down in arbitrary locations? We conceptualize place cells as perceptrons performing evidence combination across many inputs, including gridcell drives, and selecting a threshold to fire. Gridcell drives represent geometrically organized inputs in the form of multiscale periodic gridcell drive. We characterize and count which field arrangements a place cell can realize with such structured inputs. The number of realizable placefield arrangements with gridlike inputs is much larger than with onehot coded inputs of the same input dimension. However, the realizable placefield arrangements make up a vanishing fraction of all possible arrangements. We show that the “separating capacity” or spatial range over which all field arrangements are realizable is given by the rank of the gridlike input matrix, and this rank equals the sum of distinct grid periods, a small fraction of the coding range, which scales as the product of periods. Compared to random inputs over the same range, gridstructured inputs generate larger margins, conferring stability to place fields. Finally, the realizable arrangements are determined by the input geometry, thus the model predicts that place fields should lie in constrained arrangements within and across environments.

11:15  11:45 am EDTOpen Problems DiscussionProblem Session  11th Floor Lecture Hall
 Session Chairs
 Zachary Kilpatrick, University of Colorado Boulder
 Tatyana Sharpee, Salk Institute

11:50 am  12:00 pm EDTGroup Photo (Immediately After Talk)11th Floor Lecture Hall

12:00  1:30 pm EDTNetworking LunchWorking Lunch  11th Floor Collaborative Space

1:30  2:15 pm EDTToward a unifying theory of contextdependent efficient coding of sensory spaces11th Floor Lecture Hall
 Speaker
 Gaia Tavoni, Washington University in St. Louis
 Session Chair
 Tatyana Sharpee, Salk Institute
Abstract
Contextual information can powerfully influence the neural representation and perception of stimuli across the senses: multimodal cues, stimulus history, novelty, rewards, and behavioral goals can all affect how sensory inputs are encoded in the brain. Experimental findings are scattered and a top down overarching interpretation is lacking. Our goal is to develop a unifying theory of contextdependent sensory coding, beginning with the olfactory system. We use an approach based on the informationtheoretic hypothesis that optimal codes strive to maximize the overall entropy (decodability) of sensory neural representations while minimizing neural costs (e.g., in energetic terms). A novel feature of our theory is that it incorporates contextual feedback: this allows us to predict how optimal odor representations are modulated by topdown signals that represent different types of context, including the overall multisensory environment and behavioral goals. Our theory reproduces (and provides a unifying interpretation of) a large number of experimental observations. These include adaptation to familiar stimuli, background suppression and detection of novel odors in mixtures, pattern separation between similar odors after a single sniff, increased responsiveness of neurons to behaviorally salient stimuli, figureground segregation of salient odor targets. It also makes novel predictions, such as the amplification of some of these effects in ambiguous multisensory contexts, and the emergence of olfactory illusions in specific environments. Our predictions generalize to a broad class of canonical microcircuits, suggesting that the efficient coding principles uncovered here may also apply to the building blocks of other sensory systems. Finally, we show that our optimalcoding solutions can be learned in neural circuits through Hebbian synaptic plasticity. This result connects our normative findings (Marr's computational level of analysis) to biologically plausible processes (Marr's implementational level of analysis). In conclusion, we have taken significant steps towards developing a contextdependent efficient coding theory that is biologically interpretable, is broadly applicable across sensory systems, and establishes a conceptual foundation for studying sensory coding associated with behavior.

2:30  3:15 pm EDTVisual coding shaped by anatomical and functional connectivity structures11th Floor Lecture Hall
 Speaker
 Hannah Choi, Georgia Institute of Technology
 Session Chair
 Tatyana Sharpee, Salk Institute
Abstract
Visual cortical neurons encode diverse contextdependent information of visual inputs. For example, neuronal populations encode specific features of visual stimuli such as orientation, direction of movement, or object identities, while also encoding prior experience and expectations. This talk will focus on understanding how such different neural codes are shaped by both anatomical and functional connectivity of neuronal populations in the mouse visual cortex across multiple regions. In a recent experimental study, we found that lower cortical areas such as the primary visual cortex and the posterior medial higher order visual area primarily encode image identities from both expected and unexpected sequences of natural images, while neural responses in the retrosplenial cortex strongly represent expectation, in accordance with predictive coding theory. Motivated by this, we study how interareal layerspecific connectivity modulates the representation of taskrelevant information such as input identity and expectation violation by performing representational analyses on recurrent neural networks with systematically altered structural motifs. The second part of the talk will focus on how visual stimuli of varying complexity drive functional connectivity of neurons in the mouse visual cortex. Our analyses of electrophysiological data across multiple areas of visual cortex reveal that the frequencies of different loworder connectivity motifs are preserved across a range of stimulus complexity, suggesting the role of specific motifs as local computational units of visual information.

3:30  4:00 pm EDTCoffee Break11th Floor Collaborative Space

4:00  4:45 pm EDTRestructuring of olfactory representations in the fly brain around odor relationships in natural sources11th Floor Lecture Hall
 Speaker
 Betty Hong, California Institute of Technology
 Session Chair
 Tatyana Sharpee, Salk Institute
Abstract
A core challenge of olfactory neuroscience is to understand how neural representations of odor are generated and transformed through successive layers of the olfactory circuit into formats that support perception and behavior. The encoding of odor by odorant receptors in the input layer of the olfactory system reflects, at least in part, the chemical relationships between odor compounds. Neural representations of odor in higher order associative olfactory areas, generated by random feedforward networks, are expected to largely preserve these input odor relationships. We evaluated these ideas by examining how odors are represented at different stages of processing in the olfactory circuit of the vinegar fly D. melanogaster. We found that representations of odor in the mushroom body (MB), a thirdorder associative olfactory area in the fly brain, are indeed structured and invariant across flies. However, the structure of MB representational space diverged significantly from what is expected in a randomly connected network. In addition, odor relationships encoded in the MB were better correlated with a metric of the similarity of their distribution across natural sources compared to their similarity with respect to chemical features, and the converse was true for odor relationships encoded in primary olfactory receptor neurons (ORNs). Comparison of odor coding at primary, secondary, and tertiary layers of the circuit revealed that odors were significantly regrouped with respect to their representational similarity across successive stages of olfactory processing, with the largest changes occurring in the MB. The nonlinear reorganization of odor relationships in the MB indicates that unappreciated structure exists in the fly olfactory circuit, and this structure may facilitate the generalization of odors with respect to their cooccurence in natural sources.
Wednesday, November 1, 2023

9:00  9:45 am EDTInformation theoretical approaches to model synaptic plasticity11th Floor Lecture Hall
 Speaker
 Taro Toyoizumi, Riken Center for Brain Science
 Session Chair
 Horacio Rotstein, New Jersey Institute of Technology
Abstract
We adjust our behavior adaptively, based on experience, to thrive in our environment. Activitydependent synaptic plasticity within neural circuits is believed to be a fundamental mechanism that enables such adaptive behavior. In this talk, I will introduce a topdown approach to modeling synaptic plasticity. Specifically, recognizing the brain as an informationprocessing organ, I posit that synaptic plasticity mechanisms have evolved to transmit information across synapses efficiently. It suggests a method to identify hidden independent sources behind sensory scenes. I will demonstrate that it's feasible to reconstruct even nonlinearly mixed sources that underlie sensory inputs when sensors of sufficiently high dimensions are employed. Furthermore, the theory also helps in interpreting experimentally observed results: it reproduces the distinct outcomes of synaptic plasticity observed in up and down states during nonrapid eye movement sleep, shedding light on how memory consolidation might be influenced by the states and spatial scale of slow waves.

10:00  10:30 am EDTCoffee Break11th Floor Collaborative Space

10:30  11:15 am EDTTBD11th Floor Lecture Hall
 Speaker
 Nora Youngs, Colby College
 Session Chair
 Horacio Rotstein, New Jersey Institute of Technology
Abstract
Neural codes allow the brain to represent, process, and store information about the world. Combinatorial codes, comprised of binary patterns of neural activity, encode information via the collective behavior of populations of neurons. A code is called convex if its codewords correspond to regions defined by an arrangement of convex open sets in Euclidean space. What makes a neural code convex? That is, how can we tell from the intrinsic structure of a code if there exists a corresponding arrangement of convex open sets? In this talk, we will exhibit topological, algebraic, and geometric approaches to answering this question.

11:30 am  12:00 pm EDTOpen Problems DiscussionProblem Session  11th Floor Lecture Hall
 Session Chairs
 Katie Morrison, University of Northern Colorado
 Nora Youngs, Colby College

12:00  2:00 pm EDTLunch/Free Time

2:00  2:45 pm EDTIntrinsic Geometry of a Combinatorial Sensory Neural Code for Birdsong11th Floor Lecture Hall
 Speaker
 Tim Gentner, University of California, San Diego
 Session Chair
 Nora Youngs, Colby College
Abstract
To understand neural representation, researchers commonly compute receptive fields by correlating neural activity with external variables drawn from sensory signals. These receptive fields are only meaningful to the experimenter, however, because only the experimenter has access to both the neural activity and the external variables. To examine representation more directly, recent methodological advances have sought to capture the intrinsic geometry of sensory driven neural responses without external reference. To date, this approach has largely been restricted to lowdimensional stimuli as in spatial navigation. Here, we examined the intrinsic geometry of sensory representations in a model vocal communication system, songbirds. From the assumption that sensory systems represent invariant relationships among stimulus features, we conceptualized the space of natural birdsongs to lie on the surface of an ndimensional hypersphere. We computed composite receptive field models for large populations of simultaneously recorded single neurons in the caudal medial neostriatum (NCM) of the auditory forebrain and show that solutions to these models define convex regions of response probability in the spherical stimulus space. We then define a combinatorial code over the set of receptive fields, realized in the momenttomoment spiking and nonspiking patterns across the population, and show that this code can be used to reconstruct highfidelity spectrographic representations of natural songs from evoked neural responses. Notably, relationships among combinatorial codewords directly mirror acoustic relationships among songs in the spherical stimulus space. That is, the timevarying pattern of coactivity among small groups of neurons expresses an intrinsic representational geometry of natural, extrinsic stimulus space. This combinatorial sensory code for representing vocal communication signals does not require computation of receptive fields and is in a form, spike time coincidences, amenable to biophysical mechanisms of neural information propagation.

3:00  3:30 pm EDTCoffee Break11th Floor Collaborative Space

3:30  4:15 pm EDTDecoding a compact neural circuit of Caenorhabditis elegans11th Floor Lecture Hall
 Speaker
 Yuki Tsukada, Keio University
 Session Chair
 Nora Youngs, Colby College
Abstract
Caenorhabditis elegans provides a compact neural circuit consisting of 302 neurons and simple behavioral experiments for dissecting neural code. We discuss our modeling approach based on our quantitative measurements of behavior and neural activity, and systems identification framework. We are particularly focusing on thermotaxis behavior as a simple behavioral model, yet including environmental sensing, memory, learning, and decisionmaking.
Thursday, November 2, 2023

9:00  9:45 am EDTInhibitory neurons control cortical auditory processing11th Floor Lecture Hall
 Speaker
 Maria Geffen, University of Pennsylvania
 Session Chair
 Tatyana Sharpee, Salk Institute
Abstract
Sparse coding can support different forms of populationlevel codes including localist and distributed representations. In localist representations, a feature is represented by activity of a specific neuronal subpopulation. By contrast, in a distributed representation, a sensory code is represented by the relative activity of neuronal populations. These codes trade off advantages in terms of information transmission. I will present our recent findings that different inhibitory neurons differentially control these forms of information coding, by shifting the coding scheme in the auditory cortex between localist and distributed representations.

10:00  10:30 am EDTCoffee Break11th Floor Collaborative Space

10:30  11:15 am EDTMaximizing Mutual Information in Mosquito Olfaction11th Floor Lecture Hall
 Speaker
 Caitlin Lienkaemper, Boston University
 Session Chair
 Tatyana Sharpee, Salk Institute
Abstract
Across species, the olfactory system follows a conserved organization: each olfactory receptor neuron expresses a single type of olfactory receptor, and responses of olfactory sensory neurons which express the same receptor are pooled before they are sent to higher regions of the brain. Mosquitoes have recently been shown to violate this organization: olfactory sensory neurons express multiple receptor types, thus mixing information about activation of different receptors from the start. Because mosquitoes are olfactory predators, it is reasonable to assume that this pattern of coexpression makes the mosquito olfactory system more effective. Under which conditions and assumptions does coexpression of multiple receptors make sense, and how do the statistics of olfactory stimuli shape the optimal pattern of receptor expression? In a linear, feedforward model of the olfactory system with gaussian noise, we compute the level and pattern of coexpression which maximizes the mutual information between olfactory stimulus and the neural response. We find that coexpressing receptors with correlated activity maximizes the mutual information when neurons are reliable but olfactory stimuli are noisy. We then look at how the geometry of the receptor correlations interacts with the sign constraints to shape the pattern of optimal receptor expression.

11:30 am  1:30 pm EDTOpen Problems LunchWorking Lunch  11th Floor Collaborative Space

1:30  2:15 pm EDTEmergent properties of large population codes11th Floor Lecture Hall
 Speaker
 Ilya Nemenman, Emory University
 Session Chair
 Zachary Kilpatrick, University of Colorado Boulder

2:30  3:00 pm EDTCoffee Break11th Floor Collaborative Space

3:00  3:45 pm EDTMusings on mesoscale structures, brain states, and visual art, through a topological lens11th Floor Lecture Hall
 Speaker
 Shabnam Kadir, University of Hertfordshire
 Session Chair
 Zachary Kilpatrick, University of Colorado Boulder
Abstract
The neural code is sufficiently spatially and temporally smooth with respect to neural activity to enable meaningful neuroscientific recording on a large, coarse wholebrain scale, such as fMRI and EEG. We investigate the structural and functional connectome using methods from applied topology, namely persistent homology. We reveal differences in the white matter structural connectome in schizophrenia using the publicly available COBRE dataset. We also develop a method for exploring dynamic functional connectomics in fMRI which enables analysis and the derivation of brain states from a single recording and a single trial, whereas traditional fMRI analysis techniques rely on averaging over trials and subjects, disregarding individual idiosyncrasies. Finally, we explore questions of visual perception and appreciation of art in an experiment measuring EEG, eye movement, as well as conscious perception/appreciation of abstract paintings generated by both a human artist and by BigGAN.

4:00  4:45 pm EDTLearning large neural population codes, accurately, efficiently, and in a biologicallyplausible way using sparse random projections11th Floor Lecture Hall
 Virtual Speaker
 Elad Schneidman, Weizmann Institute of Science
 Session Chair
 Zachary Kilpatrick, University of Colorado Boulder
Abstract
I will present a new class of highly accurate, scalable, and efficient models of the activity of large neural populations. Moreover, I will show that these models have a biologicallyplausible implementation by neural circuits that rely on random, sparse, and nonlinear projections. I will further show that homeostatic synaptic scaling makes the learning of such models for very large neural populations even more efficient and accurate. Finally, I will discuss how such models can allow the brain to perform Bayesian decoding and the learning of metrics on the space of neural codes and of external stimuli.
Friday, November 3, 2023

9:00  9:45 am EDTRepresentational geometry of perceptual decisions11th Floor Lecture Hall
 Speaker
 Roozbeh Kiani, New York University
 Session Chair
 Katie Morrison, University of Northern Colorado
Abstract
I will explore two core principles of circuit models for perceptual decisions. In these models, neural ensembles that encode actions compete to form decisions. Consequently, representation and readout of the decision variables (DVs) in these models are similar for decisions in which the same actions compete, irrespective of input and task context differences. Further, DVs are encoded as partially potentiated action plans through balance of activity of actionselective ensembles. I show that the firing rates of neurons in the posterior parietal cortex of monkeys performing motion and face discrimination tasks violate these principles. Instead, neural responses suggest a mechanism in which decisions form along curved populationresponse manifolds misaligned with action representations. These manifolds rotate in state space for different task contexts, making optimal readout of the DV task dependent. Similar manifolds exist in lateral and medial prefrontal cortex, suggesting common representational geometries across decisionmaking circuits.

10:00  10:30 am EDTCoffee Break11th Floor Collaborative Space

10:30  11:15 am EDTSensory input to cortex encoded on lowdimensional peripherycorrelated subspaces11th Floor Lecture Hall
 Speaker
 Andrea Barreiro, Southern Methodist University
 Session Chair
 Katie Morrison, University of Northern Colorado
Abstract
As information about the world is conveyed from the sensory periphery to central neural circuits, it mixes with complex ongoing cortical activity. How do neural populations keep track of sensory signals, separating them from noisy ongoing activity? I will talk about our recent work demonstrating that sensory signals are encoded more reliably in lowdimensional subspaces defined by correlations between neural activity in primary sensory cortex and upstream sensory brain regions. We analytically show that these subspaces can reach optimal limits (without an ideal observer) as noise correlations between cortex and upstream regions are reduced, and that this principle generalizes across diverse sensory stimuli in the olfactory system and the visual system of awake mice. Finally, I will talk about the neural observations that originally motivated our thinking in this area: the difference in the olfactory response between inhale and exhale. This difference is evident early in the olfactory pathway, and we hypothesize that it arises in part because of fluid mechanical forces in the nasal cavity. I will show how we are constructing a phase preference map for mechanical forcing. Our goal is to combine this map with emerging research on receptor zones to produce a unified view of the sensory inputs underlying directional selectivity.

11:30 am  12:30 pm EDTFinal Open Problems DiscussionProblem Session  11th Floor Lecture Hall

12:30  2:00 pm EDTLunch/Free Time

3:30  4:00 pm EDTCoffee Break11th Floor Collaborative Space
Monday, November 6, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

3:00  3:30 pm ESTCoffee Break11th Floor Collaborative Space

3:30  5:00 pm ESTTLN Working GroupGroup Work  10th Floor Classroom
Tuesday, November 7, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00  10:30 am ESTIntroduction to machine learning and deep networksTutorial  10th Floor Classroom
 Cenghiz Pehlevan, Harvard

3:00  3:30 pm ESTCoffee Break11th Floor Collaborative Space
Wednesday, November 8, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00  10:00 am ESTProfessional Development: PapersProfessional Development  11th Floor Lecture Hall

10:30 am  12:00 pm ESTAnalysis of biologically plausible learning rules and contrasts with common machine learning rulesTutorial  10th Floor Classroom
 Cenghiz Pehlevan, Harvard

3:00  3:30 pm ESTCoffee Break11th Floor Collaborative Space

3:30  4:30 pm ESTFluid dynamics as a driver of retronasal olfaction11th Floor Lecture Hall
 Speaker
 Andrea Barreiro, Southern Methodist University
 Session Chair
 Peter Thomas, Case Western Reserve University
Abstract
Flavor perception is a fundamental governing factor of feeding behaviors and associated diseases such as obesity. Smells that enter the nose retronasally, i.e. from the back of the nasal cavity, play an essential role in flavor perception. Previous studies have demonstrated that orthonasal olfaction (nasally inhaled smells) and retronasal olfaction involve distinctly different brain activation, even for identical odors. Differences are evident at the glomerular layer in the olfactory bulb (Gautam et al. 2012, Sanganahalli et al. 2020) and can even be identified in the synaptic inputs to the bulb (Furudono et al. 2013). Why does the bulb receive different input based on the direction of the air flow? We hypothesize that this difference originates from fluid mechanical forces at the periphery: olfactory receptor neurons respond to mechanical, as well as chemical stimuli (Grosmaitre et al, 2007, Iwata et al, 2017). To investigate this, we use computational fluid dynamics to simulate and analyze shear stress patterns during natural inhalation and sniffing. We will show preliminary results demonstrating that shear stress forces differ for orthonasal vs. retronasal air flow; i.e. inspiration vs. exhalation, in a model of the nasal cavity. We quantify this difference with a phase preference map for mechanical forcing, analogous to the orientation preference maps used in V1. If time permits I will connect these findings to our earlier work on directional selectivity in neural network models of the olfactory bulb (Craft et al. 2021).

4:30  4:35 pm ESTLongterm participant group photosGroup Photo (Immediately After Talk)  11th Floor Lecture Hall
Thursday, November 9, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00  10:30 am ESTTDA TutorialTutorial  10th Floor Classroom
 Sameer Kailasa, University of Michigan Ann Arbor

3:00  3:30 pm ESTCoffee Break11th Floor Collaborative Space
Friday, November 10, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:30  10:30 am ESTNeuroscience knowledge required for a specific open problem10th Floor Classroom

11:00  11:30 am ESTThe Effects of Adaptation on Network Oscillation Frequency and ClusteringPost Doc/Graduate Student Seminar  10th Floor Classroom
 Ka Nap Tse, University of Pittsburgh
Abstract
In this presentation, I will explore the influence of various parameters on the oscillation frequencies of neuronal networks, with a focus on a network model consisting of excitatory and inhibitory theta neurons. Central to the discussion will be the impact of adaptation currents in excitatory neurons on oscillation frequency, particularly through inducing clustered firing patterns. The talk will also introduce a community detection algorithm and a discrete map to analyze and visualize the clustering behaviors and adaptation distribution within the network. This examination aims to provide a deeper understanding of the complex dynamics governing neuronal network function.

11:30 am  12:00 pm ESTA very slow introduction to Gabor ExpansionsPost Doc/Graduate Student Seminar  10th Floor Classroom
 Vasiliki Liontou, ICERM

1:30  3:00 pm ESTTopology+Neuro Working GroupGroup Work  10th Floor Classroom

3:00  3:30 pm ESTCoffee Break11th Floor Collaborative Space
Monday, November 13, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00  10:30 am ESTTDA TutorialTutorial  10th Floor Classroom

3:00  3:30 pm ESTCoffee Break11th Floor Collaborative Space

3:00  3:30 pm ESTWhat Determines the Frequency of Fast Network Oscillations With Irregular Neural Discharges?Journal Club  10th Floor Classroom
 Sameer Kailasa, University of Michigan Ann Arbor
 Safaan Sadiq, Pennsylvania State University

3:30  5:00 pm ESTTLN Working GroupGroup Work  10th Floor Classroom
Tuesday, November 14, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00  10:30 am ESTSynchronization and phaselocking in small neuronal networksTutorial  10th Floor Classroom
 Amitabha Bose, New Jersey Institute of Technology
Abstract
In this tutorial, using phasespace analysis, I'll go through some of the basic concepts of important network behaviors such as synchronization and antiphase oscillations. I'll show how to use geometric singular perturbation theory (GSPT) to derive lower dimensional "reduced" equations to analyze network behavior. In this context, I'll discuss some important concepts such as Fast Threshold Modulation, postinhibitory rebound and the synaptic mechanisms of escape and release. Finally, using GSPT, I'll show how to incorporate ionic currents that operate on disparate time scales in network models. Underlying all of this is an interesting exchange of information between Euclidean and time metrics which I plan to explain.

3:00  3:30 pm ESTCoffee Break11th Floor Collaborative Space
Wednesday, November 15, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00  10:00 am ESTProfessional Development: GrantsProfessional Development  11th Floor Lecture Hall

3:00  3:30 pm ESTCoffee Break11th Floor Collaborative Space

3:30  4:30 pm ESTA neuromechanstic model for keeping a beat in the context of music11th Floor Lecture Hall
 Speaker
 Amitabha Bose, New Jersey Institute of Technology
 Session Chair
 Peter Thomas, Case Western Reserve University
Abstract
While many people say they have no rhythm, most humans when listening to music can easily discern and move to a beat. On the other hand, many of us are not so adept at actually generating and maintaining a constant beat over a period of time. Demonstrating a beat is a very complicated task. Among other things, it involves the ability of our brains to estimate time intervals and to make physical movements, for example hitting a drum, in coordination with the time estimates that we make. How our brain and body solve this problem is an open and active area of research. In this talk, I will discuss a biophysical model for a group of neurons that can learn to keep a constant beat across a range of frequencies relevant to music. I will also show how to extend this model to more complex rhythmic patterns. The model leads to questions about the nature of time and the role of perception in our ability to make decisions.
Thursday, November 16, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

3:00  3:30 pm ESTCoffee Break11th Floor Collaborative Space
Friday, November 17, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

11:00  11:30 am ESTHomotopy and singular homology groups of finite graphsPost Doc/Graduate Student Seminar  11th Floor Conference Room
 Nikola Milicevic, Pennsylvania State University
Abstract
We verify analogues of classical results for higher homotopy groups and singular homology groups of (Cech) closure spaces. Closure spaces are a generalization of topological spaces that also include graphs and directed graphs and are thus a bridge that connects classical algebraic topology with the more applied side of topology, such as digital topology. More specifically, we show the existence of a long exact sequence for homotopy groups of pairs of closure spaces and that a weak homotopy equivalence induces isomorphisms for homology groups. Our main result is the construction of a weak homotopy equivalences between the geometric realizations of (directed) clique complexes and their underlying (directed) graphs. This implies that singular homology groups of finite graphs can be efficiently calculated from finite combinatorial structures, despite their associated chain groups being infinite dimensional. This work is similar to the work McCord did for finite topological spaces, but in the context of closure spaces. Our results also give a novel approach for studying (higher) homotopy groups of discrete mathematical structures such as digital images.

11:30 am  12:00 pm ESTClosedloop neuromechanical control of rhythmic motor behaviorsPost Doc/Graduate Student Seminar  11th Floor Conference Room
 Zhuojun Yu, Case Western Reserve University

1:30  3:00 pm ESTTopology+Neuro Working GroupGroup Work  11th Floor Conference Room

3:00  3:30 pm ESTCoffee Break11th Floor Collaborative Space
Monday, November 20, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

3:00  3:30 pm ESTCoffee Break11th Floor Collaborative Space

3:30  5:00 pm ESTTLN Working GroupGroup Work  10th Floor Classroom
Tuesday, November 21, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

3:00  3:30 pm ESTCoffee Break11th Floor Collaborative Space
Wednesday, November 22, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

3:00  3:30 pm ESTCoffee Break11th Floor Collaborative Space
Monday, November 27, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

3:00  3:30 pm ESTCoffee Break11th Floor Collaborative Space

3:30  5:00 pm ESTTLN Working GroupGroup Work  10th Floor Classroom
Tuesday, November 28, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00  10:30 am ESTPhase reduction for stochastic oscillators (Part I)Tutorial  10th Floor Classroom
Abstract
Phase reduction has played an important role in dynamical systems approaches to neuroscience, by reducing an ndimensional limit cycle system (such as the HodgkinHuxley equations for a regularly spiking neuron) to a 1dimensional "phase" description. In recent years, attention has also been drawn to "phaseamplitude" or "isochronisostable" reduction, which adds one or more additional dimensions beyond the phase, while keeping the dynamics as simple as possible. In the first part of the tutorial I will work through the basics of phase/amplitude reduction, and then discuss why the standard approach falls apart when one is dealing with stochastic (noisy, irregular) oscillators. In the second part of the tutorial, I will work through different approaches to phasereduction and phaseamplitude reduction that make sense whether the oscillator is noisy or not, and whether it oscillates without noise or not. The latter aspect is important as some systems (for instance conductancebased neurons in the "excitable" or subthreshold regime) do not oscillate at all unless they are driven in part by stochastic fluctuations.

3:00  3:30 pm ESTCoffee Break11th Floor Collaborative Space
Wednesday, November 29, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00  10:00 am ESTHiring ProcessProfessional Development  11th Floor Lecture Hall

10:30 am  12:00 pm ESTPhase reduction for stochastic oscillators (Part II)Tutorial  10th Floor Classroom

3:00  3:30 pm ESTCoffee Break11th Floor Collaborative Space

3:30  4:30 pm ESTOn the Relationship between Information Processing and Fitness in Biology11th Floor Lecture Hall
 Session Chair
 Peter Thomas, Case Western Reserve University
Thursday, November 30, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00  10:30 am ESTJournal ClubJournal Club  10th Floor Classroom

3:00  3:30 pm ESTCoffee Break11th Floor Collaborative Space
Friday, December 1, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:30  10:30 am EST"Something Cool I Know" Seminar10th Floor Classroom

11:00 am  12:00 pm ESTTBDPost Doc/Graduate Student Seminar  10th Floor Classroom

1:30  3:00 pm ESTTopology+Neuro Working GroupGroup Work  10th Floor Classroom

3:00  3:30 pm ESTCoffee Break11th Floor Collaborative Space
Monday, December 4, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

3:00  3:30 pm ESTCoffee Break11th Floor Collaborative Space

3:30  5:00 pm ESTOpen Problem SessionProblem Session  10th Floor Classroom
Tuesday, December 5, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

1:30  3:00 pm ESTJournal ClubJournal Club  10th Floor Classroom

3:00  3:30 pm ESTCoffee Break11th Floor Collaborative Space
Wednesday, December 6, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

10:00  11:30 am ESTOpen Problem SessionProblem Session  10th Floor Classroom

3:00  3:30 pm ESTCoffee Break11th Floor Collaborative Space

3:30  4:30 pm ESTMath + Neuro Seminar11th Floor Lecture Hall
 Session Chair
 Peter Thomas, Case Western Reserve University
Thursday, December 7, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:00  10:30 am ESTTDA TutorialTutorial  10th Floor Classroom

12:00  1:30 pm ESTOpen Problems LunchWorking Lunch  10th Floor Collaborative Space

3:00  3:30 pm ESTCoffee Break11th Floor Collaborative Space
Friday, December 8, 2023
Math + Neuroscience: Strengthening the Interplay Between Theory and Mathematics

9:30  10:30 am EST"Something Cool I Now Know" Seminar10th Floor Classroom

11:00 am  12:00 pm ESTTBDPost Doc/Graduate Student Seminar  10th Floor Classroom

1:30  3:00 pm ESTTopology+Neuro Working GroupGroup Work  10th Floor Classroom

3:00  3:30 pm ESTCoffee Break11th Floor Collaborative Space
All event times are listed in ICERM local time in Providence, RI (Eastern Standard Time / UTC5).
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